Biogen Idec, Inc.
Table of Contents

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549


FORM 8-K/A

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): November 12, 2003

Biogen Idec Inc.

(Exact name of registrant as specified in its charter)


         
Delaware
(State or other jurisdiction of
incorporation)
  0-19311
(Commission File Number)
  33-0112644
(IRS Employer
Identification No.)

14 Cambridge Center, Cambridge, Massachusetts 02142
(Address of principal executive offices) (zip code)

Registrant’s telephone number, including area code: (617) 679-2000

Not Applicable
(Former name or former address, if changed since last report)

 


TABLE OF CONTENTS

Item 7. Financial Statements and Exhibits
SIGNATURES
EXHIBIT INDEX
EX-23.2 Consent of PricewaterhouseCoopers LLP
ex-99.4 Pro Forma Financials


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This Amendment is filed solely to include the information required by Item 7(b) that was omitted from the Registrant’s initial filing on Form 8-K, filed with the Securities and Exchange Commission on November 12, 2003 in connection with the merger of Bridges Merger Corporation, a wholly owned subsidiary of the Registrant, with and into Biogen, Inc. (“Biogen”) (the “Merger).

Item 7. Financial Statements and Exhibits

  (b)   Pro forma financial information.

          The following unaudited pro forma condensed combined financial statements of the Registrant, including the notes thereto, are filed as Exhibit 99.4 hereto and are incorporated herein by reference:

    Unaudited pro forma condensed combined balance sheet combining the historical consolidated balance sheets of the Registrant and Biogen as of the nine months ended September 30, 2003, giving effect to the Merger as if it occurred on September 30, 2003

    Unaudited pro forma condensed combined statements of income of the Registrant and Biogen for the year ended December 31, 2002 and the nine months ended September 30, 2003, giving effect to the Merger as if it occurred on January 1, 2002

  (c)   Exhibits.
     
Exhibit No.   Exhibit

 
2.1*   Agreement and Plan of Merger, dated June 20, 2003, by and among the Registrant, Bridges Merger Corporation and Biogen
     
3.4**   Certificate of Amendment dated November 12, 2003 to the Amended and Restated Certificate of Incorporation of the Registrant
     
10.73**   2003 Omnibus Equity Plan of the Registrant
     
10.74**   Performance Based Management Incentive Plan of the Registrant
     
23.1**   Consent of PricewaterhouseCoopers LLP (for Biogen)
     
23.2   Consent of PricewaterhouseCoopers LLP

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Exhibit No.   Exhibit

 
99.2**   The consolidated balance sheets of Biogen and its subsidiaries at December 31, 2002 and 2001, the consolidated statements of income, cash flows and shareholders’ equity of Biogen and its subsidiaries for each of the years ended December 31, 2002, 2001 and 2000, the notes to consolidated financial statements filed along with the above referenced consolidated balance sheets, statements of income, statements of cash flows and statements of shareholders’ equity and Biogen’s Schedule II, Valuation and Qualifying Accounts and Reserves for each of the years ended December 31, 2002, 2001 and 2000
     
99.3**   The unaudited condensed consolidated balance sheet of Biogen and its subsidiaries at September 30, 2003, the unaudited condensed consolidated statements of income of Biogen and its subsidiaries for the three and nine months ended September 30, 2003 and 2002, the unaudited condensed consolidated statements of cash flows of Biogen and its subsidiaries for the nine months ended September 30, 2003 and 2002 and the notes to the condensed consolidated financial statements filed along with the above referenced unaudited condensed consolidated balance sheets, statements of income and statements of cash flows
     
99.4   The unaudited pro forma condensed combined financial statements

*   Previously filed with the SEC as an exhibit to the Registrant’s Current Report on Form 8-K (File No. 0-19311) filed on June 23, 2003, and incorporated by reference herein.
 
**   Previously filed with the SEC as an exhibit to the Registrant’s Current Report on Form 8-K (File No. 0-19311) filed on November 12, 2003, and incorporated by reference herein.

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SIGNATURES

     Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

         
    Biogen Idec Inc.
(Registrant)
         
         
Date: January 12, 2004   /s/ Thomas J. Bucknum

    By:   Thomas J. Bucknum
Executive Vice President,
General Counsel and Secretary

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EXHIBIT INDEX

     
Exhibit No.   Exhibit

 
2.1*   Agreement and Plan of Merger, dated June 20, 2003, by and among the Registrant, Bridges Merger Corporation and Biogen
     
3.4**   Certificate of Amendment dated November 12, 2003 to the Amended and Restated Certificate of Incorporation of the Registrant
     
10.73**   2003 Omnibus Equity Plan of the Registrant
     
10.74**   Performance Based Management Incentive Plan of the Registrant
     
23.1**   Consent of PricewaterhouseCoopers LLP (for Biogen)
     
23.2   Consent of PricewaterhouseCoopers LLP (for Biogen)
 
99.1**   Press release of the Registrant dated November 12, 2003
     
99.2**   The consolidated balance sheets of Biogen and its subsidiaries at December 31, 2002 and 2001, the consolidated statements of income, cash flows and shareholders’ equity of Biogen and its subsidiaries for each of the years ended December 31, 2002, 2001 and 2000, the notes to consolidated financial statements filed along with the above referenced consolidated balance sheets, statements of income, statements of cash flows and statements of shareholders’ equity and Biogen’s Schedule II, Valuation and Qualifying Accounts and Reserves for each of the years ended December 31, 2002, 2001 and 2000
     
99.3**   The unaudited condensed consolidated balance sheet of Biogen and its subsidiaries at September 30, 2003, the unaudited condensed consolidated statements of income of Biogen and its subsidiaries for the three and nine months ended September 30, 2003 and 2002, the unaudited condensed consolidated statements of cash flows of Biogen and its subsidiaries for the nine months ended September 30, 2003 and 2002 and the notes to the condensed consolidated financial statements filed along with the above referenced unaudited condensed consolidated balance sheets, statements of income and statements of cash flows
     
99.4   The unaudited pro forma condensed combined financial statements

*   Previously filed with the SEC as an exhibit to the Registrant’s Current Report on Form 8-K (File No. 0-19311) filed on June 23, 2003, and incorporated by reference herein.

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**   Previously filed with the SEC as an exhibit to the Registrant’s Current Report on Form 8-K (File No. 0-19311) filed on November 12, 2003, and incorporated by reference herein.

6

EX-23.2 Consent of PricewaterhouseCoopers LLP
 

CONSENT OF INDEPENDENT ACCOUNTANTS

We hereby consent to the incorporation by reference in the Biogen Idec Inc. (formerly known as IDEC Pharmaceuticals Corporation) Registration Statement on Form S-3 (No. 333-89792), Biogen Idec Inc. Registration Statement on Form S-4 (No. 333-107098) and Biogen Idec Inc. Registration Statements on Form S-8 (Nos. 333-97211, 333-65494, 333-47904, 333-81625, 333-110432 and 333-110433) of our report dated February 14, 2003 relating to the financial statements of Biogen, Inc., which is included as an exhibit to the Biogen Idec Inc. Current Report on Form 8-K/A dated January 12, 2004. We also consent to the incorporation by reference of our report dated February 14, 2003 relating to the financial statement schedule of Biogen, Inc., which is included as an exhibit to the Biogen Idec Inc. Current Report on Form 8-K/A dated January 12, 2004.

Boston, Massachusetts
January 12, 2004

EX-99.2 Pro Forma Financials
 

PRO FORMA FINANCIAL DATA

The Registrant and Biogen Unaudited Pro Forma Condensed Combined Financial Statements

     The following unaudited pro forma condensed combined financial statements give effect to the merger of the Registrant and Biogen in a transaction to be accounted for as a purchase with the Registrant treated as the acquirer. The unaudited pro forma condensed combined balance sheet combines the historical consolidated balance sheets of the Registrant and Biogen as of September 30, 2003, giving effect to the merger as if it occurred on September 30, 2003. The unaudited pro forma condensed combined statements of income combine the historical consolidated statements of income of the Registrant and Biogen for the year ended December 31, 2002 and the nine months ended September 30, 2003, giving effect to the merger as if it occurred on January 1, 2002, reflecting only pro forma adjustments expected to have a continuing impact on the combined results.

     These unaudited pro forma condensed combined financial statements are for informational purposes only. They do not purport to indicate the results that would have actually been obtained had the merger been completed on the assumed date or for the periods presented, or which may be realized in the future. To produce the pro forma financial information, the Registrant allocated the purchase price using its best estimates of fair value. These estimates are based on the most recently available information. To the extent there are significant changes to Biogen’s business, including results from ongoing clinical trials, the assumptions and estimates herein could change significantly. Furthermore, the parties expect to have reorganization and restructuring expenses as well as potential operating efficiencies as a result of combining the companies. The pro forma financial information does not reflect these potential expenses and efficiencies. The unaudited pro forma condensed combined financial statements should be read in conjunction with “Management’s Discussion and Analysis of Financial Condition and Results of Operations” and the historical consolidated financial statements, including the related notes, of the Registrant and Biogen covering these periods.

 


 

Biogen Idec Inc.
Unaudited Proforma Balance Sheet
As of Septmeber 30, 2003
(Amounts in thousands)

                                             
                        Pro forma   Note   Pro forma
        Registrant   Biogen   Adjustments   Reference   Combined
       
 
 
 
 
ASSETS
                                       
Current assets:
                                       
 
Cash and cash equivalents
  $ 363,678     $ 114,360     $ (27 )     A     $ 478,011  
 
Marketable securities
    483,906       811,185                       1,295,091  
 
Accounts receivable, net
    1,133       211,747       (3,791 )     J       209,089  
 
Inventories
    38,532       93,983       359,000       H       491,515  
 
Other current assets
    159,662       65,484                       225,146  
 
 
   
     
     
             
 
   
Total current assets
    1,046,911       1,296,759       355,182               2,698,852  
 
 
   
     
     
             
 
Marketable securities
    602,786                             602,786  
Property, plant & equipment
    444,207       779,379                       1,223,586  
Other assets
    145,991       56,864                       202,855  
Intangibles, net
          17,245       (17,245 )     I          
 
                    3,908,000       B       3,908,000  
Goodwill
                1,105,990       B       1,105,990  
 
 
   
     
     
             
 
   
Total assets
  $ 2,239,895     $ 2,150,247     $ 5,351,927             $ 9,742,069  
 
 
   
     
     
             
 
LIABILITIES AND STOCKHOLDERS’ EQUITY
                                       
Current liabilities:
                                       
 
Accounts payable and accrued expenses
  $ 65,716     $ 189,533       (3,791 )     J     $  
 
                    19,832       D       271,290  
 
Other current liabilites
    731       94,096       92,710       E       187,537  
 
 
   
     
     
             
 
   
Total current liabilities
    66,447       283,629       108,751               458,827  
 
 
   
     
     
             
 
Notes payable
    881,956       34,161                       916,117  
Deferred tax liabilities
          33,696       1,054,213       E       1,087,909  
Other liabilities
    29,548       21,835       15,412       F       66,795  
 
 
   
     
     
             
 
   
Total liabilities
    977,951       373,321       1,178,376               2,529,648  
 
 
   
     
     
             
 
Stockholders’ equity:
                                       
 
Convertible preferred stock
                                 
 
Common stock
    79       1,517       (1,517 )     G          
 
                    86       A       165  
 
Additional paid-in-capital
    1,016,034       842,427       (842,427 )     G          
 
                    6,480,253       A          
 
                    295,399       A       7,791,686  
 
Accumulated other comprehensive income
    2,189       34,193       (34,193 )     G       2,189  
 
Retained earnings (deficit)
    378,642       957,484       (957,484 )     G          
 
                    (823,000 )     C       (444,358 )
 
Deferred compensation
                    (2,261 )     K       (2,261 )
 
Less treasury stock, at cost
    135,000       58,695       (58,695 )     G       135,000  
 
 
   
     
     
             
 
   
Total stockholders’ equity
    1,261,944       1,776,926       4,173,551               7,212,421  
 
 
   
     
     
             
 
   
Total liabilities and stockholders’ equity
  $ 2,239,895     $ 2,150,247     $ 5,351,927             $ 9,742,069  
 
 
   
     
     
             
 

 


 

Biogen Idec Inc.
Unaudited Proforma Statement of Operations
For the Nine Months Ended September 30, 2003
(Amounts in thousands)

                                             
                        Pro forma   Note   Pro forma
        Registrant   Biogen   Adjustments   Reference   Combined
       
 
 
 
 
Revenues:
                                       
 
Product sales
  $ 15,069     $ 881,435                     $ 896,504  
 
Royalties
            100,439                       100,439  
 
Revenues from unconsolidated joint business
    363,236                               363,236  
 
Corporate partner revenues
    1,032       6,253       (6,253 )     J       1,032  
 
   
     
     
             
 
   
Total revenues
    379,337       988,127       (6,253 )             1,361,211  
 
   
     
     
             
 
Operating costs and expenses:
                                       
 
Cost of sales
    5,282       146,176                       151,458  
 
Research and development
    113,122       325,623       (6,253 )     J          
 
                    252       M          
 
                    1,251       I       433,995  
 
Selling, general and administrative
    83,247       283,592       434       M          
 
                    180       P       367,453  
 
Amortization of intangibles
                    196,776       L       196,776  
 
   
     
     
             
 
   
Total operating costs and expenses
    201,651       755,391       192,640               1,149,682  
 
   
     
     
             
 
Income from operations
    177,686       232,736       (198,893 )             211,529  
 
   
     
     
             
 
Other income (expense), net
    8,549       12,556                       21,105  
 
   
     
     
             
 
Income before income taxes
    186,235       245,292       (198,893 )             232,634  
Income taxes
    70,769       68,682       (36,860 )     N       102,591  
 
   
     
     
             
 
Net income
  $ 115,466     $ 176,610     $ (162,033 )           $ 130,043  
 
   
     
     
             
 
Basic earnings per share
  $ 0.74                             $ 0.40  
 
   
                             
 
Diluted earnings per share
  $ 0.67                             $ 0.38  
 
   
                             
 
Shares used in calculating earnings per share:
                                       
 
Basic
    155,117       149,746       (149,746 )     O          
 
   
     
                         
 
                    172,208       O       327,325  
 
                                   
 
 
Diluted
    181,050       151,586       (151,586 )     O          
 
   
     
                         
 
                    174,660       O       355,710  
 
                                   
 

 


 

Biogen Idec Inc.
Unaudited Proforma Statement of Operations
For the Year Ended December 31, 2002
(Amounts in thousands)

                                             
                        Pro forma   Note   Pro forma
        Registrant   Biogen   Adjustments   Reference   Combined
       
 
 
 
 
Revenues:
                                       
 
Product sales
  $ 13,711     $ 1,034,357                     $ 1,048,068  
 
Royalties
            114,007                       114,007  
 
Revenues from unconsolidated joint business
    385,809                             385,809  
Corporate partner revenues
    4,702                             4,702  
 
   
     
     
             
 
   
Total revenues
    404,222       1,148,364                     1,552,586  
 
   
     
     
             
 
Operating costs and expenses:
                                       
 
Cost of sales
    1,457       160,159                       161,616  
 
Research and development
    93,648       367,567       337       M          
 
                    (568 )     I       460,984  
 
Selling, general and administrative
    95,241       324,001       578       M          
 
                    240       P       420,060  
 
Amortization of intangibles
                    262,368       L       262,368  
 
   
     
     
             
 
   
Total operating costs and expenses
    190,346       851,727       262,955               1,305,028  
 
   
     
     
             
 
Income from operations
    213,876       296,637       (262,955 )             247,558  
 
   
     
     
             
 
 
Other income (expense), net
    17,646       (20,042 )                     (2,396 )
 
   
     
     
             
 
Income (loss) before income taxes
    231,522       276,595       (262,955 )             245,162  
Income tax provision (benefits)
    83,432       77,447       (49,147 )     N       111,732  
 
   
     
     
             
 
Net income (loss)
  $ 148,090     $ 199,148     $ (213,808 )           $ 133,430  
 
   
     
     
             
 
Basic earnings per share
  $ 0.97                             $ 0.41  
 
   
                             
 
Diluted earnings per share
  $ 0.85                             $ 0.40  
 
   
                             
 
Shares used in calculating earnings per share:
                                       
 
Basic
    153,086       149,337       (149,337 )     O          
 
   
     
                         
 
                    171,738       O       324,824  
 
                                   
 
 
Diluted
    179,634       151,930       (151,930 )     O          
 
   
     
                         
 
                    174,720       O       354,354  
 
                                   
 

 


 

Notes To Unaudited Pro Forma Condensed Combined
Financial Statements

1. Description of Transaction and Basis of Presentation

     On November 12, 2003, the Registrant and Biogen completed a merger of equals transaction in which a wholly owned subsidiary of the Registrant was merged with and into Biogen in a transaction accounted for as a purchase under accounting principles generally accepted in the United States of America. Under the purchase method of accounting, the assets and liabilities of Biogen were recorded as of the acquisition date, at their fair values and added to those of the Registrant. The reported financial condition and results of operations of the Registrant will reflect these values, but will not be restated retroactively to reflect historical financial position or results of operations at Biogen. The transaction qualified as a reorganization within the meaning of Section 368(a) of the Internal Revenue Code. Under the terms of the merger agreement, each share of Biogen common stock outstanding at the closing of the merger was exchanged for 1.15 shares of the Registrant common stock, plus cash in lieu of fractional shares. In addition, each option to purchase Biogen common stock outstanding at the closing of the merger was assumed by the Registrant and thereafter constituted an option to acquire the number of shares of the Registrant common stock determined by multiplying the number of shares of Biogen common stock subject to the option immediately prior to the merger by 1.15, rounded down to the nearest whole share, with an exercise price equal to the exercise price of the assumed Biogen option divided by 1.15, rounded up to the nearest whole cent. Each of these options is subject to the same terms and conditions that were in effect for the related Biogen options.

2. Purchase Price

     A preliminary estimate of the purchase price is as follows (table in thousands):

         
Fair value of the Registrant common stock
  $ 6,480,339  
Fair value of replacement stock options
    295,399  
Cash paid for fractional shares
    27  
Acquisition costs (est)
    19,832  
 
   
 
Total purchase price
  $ 6,795,597  
 
   
 

The fair value of the Registrant shares used in determining the purchase price was $37.69 per share based on the average of the closing price of the Registrant common stock for the period two days before through two days after the announcement of the merger on June 23, 2003. The fair value of the Registrant stock options issued was determined using the Black-Scholes option pricing model with the following assumptions: stock price of $37.69, which is the value ascribed to the Registrant shares in determining the purchase price; volatility of 40%; risk-free interest rate of 1.8%; and an expected life of 4.0 years.

 


 

The estimated purchase price has been allocated to the acquired tangible and intangible assets and liabilities based on their estimated fair values as of September 30, 2003 (table in thousands):

         
Inventory
  $ 452,983  
Accounts receivable
    211,747  
Property, plant and equipment
    779,379  
Acquired identifiable intangible assets
    3,908,000  
Goodwill
    1,105,990  
In-process research and development
    823,000  
Deferred stock-based compensation
    2,261  
Other current and long-term assets
    1,047,893  
Assumed liabilities
    (373,321 )
Increase benefit plan liability to fair value
    (15,412 )
Deferred tax liabilities arising from fair value adjustments
    (1,146,923 )
 
   
 
Total purchase price
  $ 6,795,597  
 
   
 

The allocation of the purchase price is preliminary. The final determination of the purchase price allocation will be based on the fair values of assets acquired, including the fair values of in-process research and development, other identifiable intangibles and deferred stock-based compensation and the fair values of liabilities assumed as of November 12, 2003, the date that the merger was consummated. The excess of the purchase price over the fair value of assets and liabilities acquired is allocated to goodwill. The purchase price allocation will remain preliminary until the Registrant completes a third-party valuation of significant identifiable intangible assets acquired (including in-process research and development) and determines the fair values of other assets and liabilities acquired. The final determination of the purchase price allocation will be completed as soon as practicable. The final amounts allocated to assets and liabilities acquired could differ significantly from the amounts presented in the unaudited pro forma condensed combined financial statements.

     The amount allocated to acquired identifiable intangible assets has been attributed to the following categories (table in thousands):

         
Patents
  $ 604,000  
Trademarks
    112,000  
Core technology
    3,192,000  
 
   
 
 
  $ 3,908,000  
 
   
 

     The estimated fair value attributed to core technology, which relates to Biogen’s existing FDA-approved products, was determined based on a discounted forecast of the estimated net future cash flows to be generated from the technology. The estimated fair value attributed to core technology will be amortized over 15 to 21 years which is the estimated period over which cash flows will be generated from the technology.

     The estimated fair value attributed to patents represents only those patents from which Biogen derives cash flows through contractual third-party out-licensing activity and not patents related to Biogen’s current product portfolio or in-process research projects. The estimated fair value was determined based on a discounted forecast of the estimated net future cash flows to be generated from the patents. The estimated fair value attributed to patents will be amortized over 12 years which is the estimated period over which cash flows will be generated from the patents.

 


 

     The amount allocated to in-process research and development represents an estimate of the fair value of purchased in-process technology for research projects that, as of the expected closing date of the merger, will not have reached technological feasibility and have no alternative future use. Only those research projects that had advanced to a stage of development where management believed reasonable net future cash flow forecasts could be prepared and a reasonable likelihood of technical success existed were included in the estimated fair value. Accordingly, the in-process research and development primarily represents the estimated fair value of ANTEGREN, Biogen’s drug currently in Phase III development for Crohn’s disease and multiple sclerosis. The estimated fair value of the in-process research and development was determined based on a discounted forecast of the estimated net future cash flows for each project, adjusted for the estimated probability of technical success and FDA approval for each research project. In-process research and development will be expensed immediately following consummation of the merger.

3. Pro forma adjustments

  (A)   To record the value of the Registrant common stock and stock options issued in the merger. Cash paid in lieu of fractional shares of approximately $27,000 was from existing cash balances.

  (B)   To record the estimated fair values of acquired identifiable intangible assets and goodwill arising from the merger.

  (C)   To record the estimated fair value of in-process research and development acquired in the merger. Because this expense is directly attributable to the acquisition and will not have a continuing impact, it is not reflected in the pro forma condensed combined statements of income. However, this item will be recorded as an expense immediately following consummation of the merger.

  (D)   To record the estimated the Registrant transaction costs of $19.8 million; transaction costs incurred by Biogen were expensed as incurred.

  (E)   To record the deferred tax liabilities resulting from book-tax basis differences attributable to the fair value adjustments.

  (F)   To record the projected benefit obligation associated with Biogen’s defined benefit plan at its estimated fair value.

  (G)   To eliminate Biogen’s historical stockholders’ equity accounts.

  (H)   To record the estimated step-up of Biogen’s inventory from book value to fair value. The step-up in the fair value of Biogen’s inventory equals the difference between the carrying value of the inventory and the market value of the inventory determined using the net realizable value method. In accordance with SFAS 141, paragraph 37(c), Biogen’s inventory was valued as follows:

    Raw materials inventory was valued at estimated current replacement cost, which is equal to the carrying value.
    Work in process inventory was valued at the estimated selling price of finished goods less the sum of costs to complete, costs of disposal, and a reasonable profit allowance on the selling efforts and manufacturing/completion efforts.
    Finished goods inventory was valued at the estimated selling price less the sum of costs of disposal and a reasonable profit allowance on the selling effort.

 


 

         Profit allowance on the selling efforts and manufacturing efforts, respectively, is determined based on the relative levels of selling costs and manufacturing costs. The step-up of Biogen’s inventory is allocated to the components of inventory as follows (table in thousands):
         
Raw materials
  $  
WIP
    307,000  
Finished goods
    52,000  
 
   
 
Total
  $ 359,000  
 
   
 

    The fair value step-up of inventory will result in a $359 million decrease in gross margin as the inventory is sold, following consummation of the merger. This impact has not been reflected in the pro forma condensed combined statements of income because it is a material non-recurring charge that will be reflected in operations in the 12-month period following the merger.
 
         The impact of the step up of property, plant and equipment is expected to be immaterial, therefore there has been no adjustment in these pro forma financial statements.

  (I)   To adjust amounts related to Biogen’s capitalized patent costs to conform Biogen’s accounting policy to the Registrant’s accounting policy for patents.

  (J)   To eliminate balances and transactions between the Registrant and Biogen under an existing collaboration agreement which, upon completion of the merger, would be considered intercompany balances and transactions.

  (K)   To record the deferred stock-based compensation related to unvested Biogen options assumed by the Registrant in the merger. The amount of the deferred compensation was based on the portion of the intrinsic value of the Biogen options that relates to the future vesting period. The intrinsic value was measured as the difference between the assumed value of the Registrant shares issued in the merger of $37.69 per share and the exercise price of the assumed Biogen options after giving consideration to the exchange of the Biogen options for the Registrant options.

  (L)   To reflect the amortization of acquired identifiable intangible assets.

  (M)   To reflect the amortization of deferred stock-based compensation associated with assumed unvested Biogen options. The deferred compensation is being amortized over the average remaining vesting period of the assumed options. The amortization expense has been recorded in the expense category associated with the payroll classification of the grantee which is expected to be primarily research and development and selling, general and administrative. The impact to cost of sales is expected to be insignificant, therefore there has been no adjustment in these pro forma financial statements.

  (N)   To reflect the tax effect of the pro forma adjustments, including the amortization of acquired identifiable intangible assets and deferred stock-based compensation. These adjustments as well as the impact of adding Biogen’s income to calculate the Registrant’s tax provision would result in an increase in the Registrant’s effective tax rate from 38% to 44% for the nine months ended September 30, 2003 and from 36% to 46% for the year ended December 31, 2002.

  (O)   To eliminate Biogen’s weighted average shares outstanding, to reflect the issuance of the Registrant shares in the merger and to reflect the dilutive effect of the issuance of the Registrant stock options in exchange for Biogen stock options.

  (P)   To reflect the impact of the employment agreement with the combined company’s Executive Chairman which is directly attributable to the merger.