1
                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                    FORM 10-Q

(Mark One)
[X]             QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d)
                     OF THE SECURITIES EXCHANGE ACT OF 1934
                For the quarterly period ended September 30, 1996

                                       OR

[ ]            TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d)
                     OF THE SECURITIES EXCHANGE ACT OF 1934
                   For the transition period from ____ to ____

Commission file number: 0-19311


                        IDEC PHARMACEUTICALS CORPORATION
             (Exact name of registrant as specified in its charter)


California                                                          33-0112644
(State or other jurisdiction of                               (I.R.S. Employer
incorporation or organization)                             Identification No.)


                11011 Torreyana Road, San Diego, CA                 92121
              (Address of principal executive offices)           (Zip code)

                                 (619) 550-8500
              (Registrant's telephone number, including area code)




Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the preceding 12 months (or for such shorter period that the registrant was
required to file such reports), and (2) has been subject to such filing
requirements for the past 90 days. Yes _X_ No ___


As of October 31, 1996, the Registrant had 18,016,354 shares of its common
stock, no par value issued and outstanding.
   2
                        IDEC PHARMACEUTICALS CORPORATION

                          FORM 10-Q -- QUARTERLY REPORT
                FOR THE QUARTERLY PERIOD ENDED SEPTEMBER 30, 1996

                                TABLE OF CONTENTS



                                                                                                     
PART I. FINANCIAL INFORMATION

Item 1. Financial Statements

        Condensed Consolidated Balance Sheets -- September 30, 1996 and December 31, 1995 ..........     1
        Condensed Consolidated Statements of Operations -- Three months ended September 30, 1996 and
           1995 and nine months ended September 30, 1996 and 1995 ..................................     2
        Condensed Consolidated Statements of Cash Flows -- Nine months ended September 30, 1996 and
           1995 ....................................................................................     3
        Notes to Condensed Consolidated Financial Statements .......................................     4

Item 2. Management's Discussion and Analysis of Financial Condition and Results of Operations ......     5

PART II. OTHER INFORMATION

Item 1. Legal Proceedings ..........................................................................    12

Item 2. Changes in Securities ......................................................................    12

Item 3. Defaults upon Senior Securities ............................................................    12

Item 4. Submission of Matters to a Vote of Shareholders ............................................    12

Item 5. Other Information ..........................................................................    12

Item 6. Exhibits and Reports on Form 8-K ...........................................................    12
3 PART I -- FINANCIAL INFORMATION Item 1. FINANCIAL STATEMENTS. IDEC PHARMACEUTICALS CORPORATION AND SUBSIDIARY CONDENSED CONSOLIDATED BALANCE SHEETS (In thousands)
September 30, December 31, 1996 1995 --------- -------- (unaudited) ASSETS Current assets: Cash and cash equivalents $ 53,105 $ 18,828 Securities available-for-sale 22,971 5,182 Current portion of note receivable 761 640 Contract research revenue receivables 2,850 1,455 Inventories 1,729 -- Prepaid expenses and other current assets 2,944 1,333 --------- -------- Total current assets 84,360 27,438 Property and equipment, net 17,921 17,955 Restricted marketable security -- 750 Note receivable, less current portion 672 1,249 Deposits and other assets 341 234 --------- -------- $ 103,294 $ 47,626 ========= ======== LIABILITIES AND SHAREHOLDERS' EQUITY Current liabilities: Current portion of notes payable $ 3,656 $ 3,248 Trade payable - clinical materials -- 238 Accounts payable 1,291 970 Accrued expenses 4,105 4,280 --------- -------- Total current liabilities 9,052 8,736 Notes payable, less current portion 5,386 6,598 Other long-term liabilities 2,402 1,123 Shareholders' equity (Note 2): Convertible preferred stock, no par value 26,586 14,086 Common stock, no par value 142,426 93,554 Additional paid-in capital 2,449 2,379 Unrealized gains on securities available-for-sale -- 10 Accumulated deficit (85,007) (78,860) --------- -------- Total shareholders' equity 86,454 31,169 --------- -------- $ 103,294 $ 47,626 ========= ========
See accompanying notes to condensed consolidated financial statements. 1 4 IDEC PHARMACEUTICALS CORPORATION AND SUBSIDIARY CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (In thousands, except per share data) (unaudited)
Three months Nine months ended September 30, ended September 30, ------------------------ ------------------------ 1996 1995 1996 1995 -------- -------- -------- -------- Revenues: Sales $ -- $ -- $ 1,505 $ -- Contract research revenues 2,902 1,375 8,902 6,924 License fees -- 1,000 9,500 6,000 -------- -------- -------- -------- 2,902 2,375 19,907 12,924 Operating expenses: Cost of sales -- -- 1,384 -- Research and development 6,292 5,347 19,011 16,280 General and administrative 1,844 1,672 5,305 4,677 Acquired technology rights -- -- -- 11,437 -------- -------- -------- -------- 8,136 7,019 25,700 32,394 -------- -------- -------- -------- Loss from operations (5,234) (4,644) (5,793) (19,470) Interest income (expense), net 730 (279) (354) (484) -------- -------- -------- -------- Net loss $ (4,504) $ (4,923) $ (6,147) $(19,954) ======== ======== ======== ======== Net loss per common share $ (0.26) $ (0.32) $ (0.38) $ (1.37) ======== ======== ======== ======== Shares used in computing net loss per common share 17,528 14,869 16,127 14,550 ======== ======== ======== ========
See accompanying notes to condensed consolidated financial statements. 2 5 IDEC PHARMACEUTICALS CORPORATION AND SUBSIDIARY CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (In thousands) (unaudited)
Nine months ended September 30, ------------------------ 1996 1995 -------- -------- Cash flows from operating activities: Net cash used in operating activities $ (5,926) $ (7,967) -------- -------- Cash flows from investing activities: Purchase of property and equipment (1,993) (848) Purchase of securities available-for-sale (31,324) (6,888) Sales and maturities of securities available-for-sale 14,274 2,492 -------- -------- Net cash used in investing activities (19,043) (5,244) -------- -------- Cash flows from financing activities: Proceeds from notes payable 1,790 2,785 Payments on notes payable (2,557) (3,321) Net proceeds from issuance of common stock 47,513 210 Proceeds from issuance of preferred stock 12,500 7,149 -------- -------- Net cash provided by financing activities 59,246 6,823 -------- -------- Net increase (decrease) in cash and cash equivalents 34,277 (6,388) Cash and cash equivalents, beginning of period 18,828 13,691 -------- -------- Cash and cash equivalents, end of period $ 53,105 $ 7,303 ======== ========
See accompanying notes to condensed consolidated financial statements. 3 6 IDEC PHARMACEUTICALS CORPORATION AND SUBSIDIARY NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited) NOTE 1. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES Basis of Presentation The information at September 30, 1996, and for the three and nine months ended September 30, 1996 and 1995, is unaudited. In the opinion of management, these financial statements include all adjustments, consisting of normal recurring adjustments, necessary for a fair presentation of results for the interim periods presented. Interim results are not necessarily indicative of results for a full year. These financial statements should be read in conjunction with IDEC Pharmaceuticals Corporation's Annual Report on Form 10-K for the year ended December 31, 1995, which was filed with the United States Securities and Exchange Commission on April 1, 1996. Inventories Inventories are stated at the lower of cost or market. Cost is determined in a manner which approximates the first-in, first-out (FIFO) method. New Accounting Standards Effective January 1, 1996, the Company adopted Financial Accounting Standards Board Statement No. 123, "Accounting for Stock-Based Compensation" ("Statement 123"). Statement 123 allows companies to expand the use of fair value accounting for stock compensation plans or requires companies that elect to retain the current approach for recognizing stock-based compensation expense to make annual pro forma disclosures of the Company's operating results as if they had adopted the fair value method. Management of the Company has retained the current approach for recognizing stock-based compensation which did not have a financial effect on the Company's consolidated financial statements and will report the annual pro forma disclosures in the notes to the fiscal 1996 consolidated financial statements. Effective January 1, 1996, the Company adopted Financial Accounting Standards Board Statement No. 121, "Accounting for the Impairment of Long-Lived Assets and for Long-Lived Assets to be Disposed Of" ("Statement 121"). Statement 121 requires impairment of losses to be recorded on long-lived assets used in operations when indicators of impairment are present and the undiscounted cash flows estimated to be generated by those assets are less than the assets' carrying amount. The adoption of Statement 121 did not have a material effect on the Company's consolidated financial statements for the three and nine months ended September 30, 1996. NOTE 2. SHAREHOLDERS' EQUITY Common Stock In June 1996, the Company completed a public offering of 2,070,000 shares of its common stock resulting in net proceeds of approximately $46,300,000. Convertible Preferred Stock The Company issued 23,000 shares of its Series A-3 Nonvoting Convertible Preferred Stock ("Series A-3 Preferred Stock") in March 1996, and 100,000 shares of its Series A-6 Nonvoting Convertible Preferred Stock ("Series A-6 Preferred Stock") in May 1996, to Genentech, Inc. pursuant to the terms of a preferred stock purchase agreement. The preferred stock purchase agreement was entered into concurrently with a collaboration agreement in March 1995. The Series A-3 Preferred Stock and Series A-6 Preferred Stock are recorded on the balance sheet at their liquidation preference per share of $217 and $75, respectively. Each share of Series A-3 Preferred Stock is convertible at any time into ten shares of common stock. Each share of Series A-6 Preferred Stock is convertible into the number of shares of common stock equal to 75 divided by the average closing price of the Company's common stock as reported by the Nasdaq National Market for the 20 trading days following the earlier of (i) the FDA approval date for IDEC-C2B8 or (ii) September 16, 2000. 4 7 ITEM 2. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS OVERVIEW Since its inception, IDEC Pharmaceuticals Corporation (the "Company") has been primarily engaged in the research and development of products for the long-term management of immune system cancers and autoimmune and inflammatory diseases. To date, the Company has not received any revenues from the commercial sale of its products. The Company has funded its operations primarily through the sale of equity securities as well as through contract research and license fee revenues received in connection with collaborative arrangements entered into with the Company's strategic partners. For the nine months ended September 30, 1996 and the year ended December 31, 1995, the Company recognized contract research and license fee revenues of $18.4 million and $23.6 million, respectively. The Company has incurred increasing annual operating expenses and, as the Company moves closer to product commercialization, it expects such trends to continue. The Company has incurred annual operating losses since its inception in 1985, and anticipates that such operating losses will continue for at least the next one to two years. As of September 30, 1996, the Company had an accumulated deficit of $85.0 million. RESULTS OF OPERATIONS Contract research revenues for the three and nine months ended September 30, 1996 totaled $2.9 million and $8.9 million, respectively, compared to $1.4 million and $6.9 million for the comparable periods in 1995. The increase in contract research revenues for the three and nine months ended September 30, 1996 is due primarily to revenue from a new collaboration entered into with Eisai Co., Ltd. in December 1995, partially offset by decreased revenues from SmithKline Beecham, p.l.c. ("SmithKline Beecham") as a result of the planned transfer of clinical development of IDEC-CE9.1 to SmithKline Beecham in late 1995. License fees for the nine months ended September 30, 1996 totaled $9.5 million compared to $6.0 million for the comparable period in 1995. The increase in the license fees is due primarily to $4.5 million received for the license to Chugai Pharmaceutical Co., Ltd. of the Company's proprietary gene expression technology for the manufacture of recombinant proteins. Sales and costs of sales for the nine months ended September 30, 1996 were a result of the Company completing a contract manufacturing arrangement during the second quarter of 1996. Research and development expenses equaled $6.3 million and $5.3 million for the third quarters of 1996 and 1995, respectively, and $19.0 million and $16.3 million for the nine months ended September 30, 1996 and 1995, respectively. The increase in research and development expenses for the three months ended September 30, 1996, is primarily due to increased personnel costs related to the completion of the Phase III trial, preparation of the Biologics License Application and the preparation for building of commercial inventory of the Company's lead product candidate, IDEC-C2B8. The increase in research and development expenses for the nine months ended September 30, 1996 is primarily due to a $1.3 million expense for access to certain patent rights related to IDEC-C2B8, increased personnel costs related to the completion of the Phase III trial, preparation of the Biologics License Application and the preparation for building of commercial inventory of the Company's lead product candidate, IDEC-C2B8. The Company expects to continue incurring substantial additional research and development costs in the future, due to expansion of research and development programs; patent and regulatory related costs; preclinical and clinical testing of the Company's various products under development; production scale-up and manufacturing of products used in clinical trials; and pre-commercialization-related manufacturing costs. General and administrative expenses were $1.8 million and $1.7 million for the third quarters of 1996 and 1995, respectively, and $5.3 million and $4.7 million for the nine months ended September 30, 1996 and 1995, respectively. General and administrative expenses for the nine months ended September 30, 1996, increased due to higher personnel costs to support expanded manufacturing operations, completion of the Phase III trial and preparation of the Biologics License Application for IDEC-C2B8. General and administrative costs necessary to support expanded manufacturing operations, expanded product development efforts and the creation of a marketing and sales organization are expected to continue to increase in the foreseeable future. 5 8 Beginning in 1988, the Company obtained funds from ML/MS Associates, L.P. ("ML/MS") for the development of the Company's lymphoma products. In connection with such funding, ML/MS obtained rights in such products. In March 1995, the Company repurchased such rights by the issuance of 1.0 million shares of its common stock and 69,375 shares of 10% Series B Nonvoting Cumulative Convertible Preferred Stock to ML/MS. In March 1995, the Company recorded a noncash charge of $11.4 million, representing the purchase of the acquired technology rights. Net interest income totaled $0.7 million for the three months ended September 30, 1996 compared to net interest expense of $0.3 million for the three months ended September 30, 1995. Net interest expense totaled $0.3 million for the nine months ended September 30, 1996 compared to $0.5 million for the comparable period in 1995. Net interest income was generated for the three months ended September 30, 1996 from the increase in cash, cash equivalents and securities available-for-sale resulting from the completion of a public offering of 2.1 million shares in June 1996. LIQUIDITY AND CAPITAL RESOURCES The Company has financed its operations and capital expenditures since inception principally through the sale of equity securities, license fees, contract research revenues, lease financing transactions and interest income. The Company expects to finance its current and planned operating requirements principally through cash on hand and with funds from existing collaborative agreements and contracts which the Company believes will be sufficient to meet its near-term operating requirements. Existing agreements and contracts, however, could be canceled by the contracting parties. In addition, the Company may pursue additional capital through a combination of new collaborative agreements, strategic alliances, equity and debt financings. However, no assurance can be provided that additional capital will be obtained through these sources on favorable terms or at all. Should the Company not enter into any such arrangements, the Company anticipates its cash, cash equivalents and securities available-for-sale, together with the existing agreements and contracts, will be sufficient to finance the Company's currently anticipated needs for operating and capital expenditures through early commercialization of its first product. If adequate funds are not available from additional sources of financing, the Company's business could be adversely affected. The Company's working capital and capital requirements will depend upon numerous factors, including the progress of the Company's preclinical and clinical testing; manufacturing; research and development programs; timing and cost of obtaining regulatory approvals; levels of resources that the Company devotes to the development of manufacturing and marketing capabilities; technological advances; status of competitors; and the ability of the Company to establish collaborative arrangements with other organizations. Until required for operations, the Company's policy under established guidelines is to keep its cash reserves in bank deposits, certificates of deposit, commercial paper, corporate notes, United States government instruments and other readily marketable debt instruments, all of which are investment-grade quality. At September 30, 1996, the Company had $76.1 million in cash, cash equivalents and securities available-for-sale compared to cash, cash equivalents and securities available-for-sale of $24.0 million at December 31, 1995. Sources of cash, cash equivalents and securities available-for-sale for the nine months ended September 30, 1996 include $12.5 million from the issuance of convertible preferred stock, $47.5 million from the issuance of common stock (including approximately $1.2 million from the exercise of stock options and from common stock issued under an employee stock purchase plan) and $1.8 million from funding under an existing lease line. Uses of cash, cash equivalents and securities available-for-sale during the nine months ended September 30, 1996 include $5.9 million used in operations, $2.0 million used to purchase capital equipment and $2.6 million used to pay notes payable. In June 1996, the Company completed a public offering of 2,070,000 shares of its common stock resulting in net proceeds of approximately $46.3 million. In May 1996, the Company issued 100,000 shares of its Series A-6 Convertible Preferred Stock and in March 1996, the Company issued 23,000 shares of its Series A-3 Convertible Preferred Stock pursuant to terms of a preferred stock purchase agreement with Genentech, Inc. ("Genentech") resulting in proceeds of $12.5 million. In August 1995, the Company completed funding under a $10.0 million lease financing agreement to finance both equipment and facility improvements. Terms of the financing agreement require final principal payments of $1.1 million and $0.4 million in July 1998 and January 1999, respectively. 6 9 This quarterly report contains predictions, estimates and other forward-looking statements that involve a number of risks and uncertainties. While this outlook represents management's current judgment on the future direction of the business, such risks and uncertainties could cause actual results to differ materially from any future performance suggested above. The Company undertakes no obligation to release publicly the results of any revisions to these forward-looking statements to reflect events or circumstances arising after the date hereof. RISK FACTORS Uncertainties Associated with Clinical Trials The Company has conducted and plans to continue to undertake extensive and costly clinical testing to assess the safety, efficacy and applicability of its potential products. The rate of completion of the Company's clinical trials is dependent upon, among other factors, the rate of patient enrollment. Patient enrollment is a function of many factors, including the nature of the Company's clinical trial protocols, existence of competing protocols, size of the patient population, proximity of patients to clinical sites and eligibility criteria for the study. Delays in patient enrollment will result in increased costs and delays, which could have a material adverse effect on the Company. The Company cannot assure that patients enrolled in the Company's clinical trials will respond to the Company's product candidates. Setbacks are to be expected in conducting human clinical trials. Failure to comply with the United States Food and Drug Administration ("FDA") regulations applicable to such testing can result in delay, suspension or cancellation of such testing, and/or refusal by the FDA to accept the results of such testing. In addition, the FDA may suspend clinical trials at any time if it concludes that the subjects or patients participating in such trials are being exposed to unacceptable health risks. Further, there can be no assurance that human clinical testing will show any current or future product candidate to be safe and effective or that data derived therefrom will be suitable for submission to the FDA or will support the Company's submission of a Biologics License Application ("BLA"). Reliance on Third Party Development and Marketing Efforts The Company has adopted a research, development and product commercialization strategy that is dependent upon various arrangements with strategic partners and others. The success of the Company's products is substantially dependent upon the success of these outside parties in performing their obligations, which include, but are not limited to, providing funding, performing research and development, fulfilling long-term manufacturing demands and marketing, distribution and sales with respect to the Company's products. The Company's strategic partners may also develop products that may compete with the Company. Although the Company believes that its partners have an economic incentive to succeed in performing their contractual obligations, the amount and timing of resources that they devote to these activities is not within the control of the Company. There can be no assurance that these parties will perform their obligations as expected or that any revenue will be derived from such arrangements. The Company has entered into collaborative agreements with Genentech, Zenyaku Kogyo, Ltd. ("Zenyaku"), SmithKline Beecham, Mitsubishi Chemical Corporation ("Mitsubishi"), Seikagaku Corporation ("Seikagaku") and Eisai Co., Ltd. ("Eisai"). These agreements generally may be terminated at any time by the strategic partner, typically on short notice to the Company. If one or more of these partners elect to terminate their relationship with the Company, or if the Company or its partners fail to achieve certain milestones, it could have a material adverse effect on the Company's ability to fund the related programs and to develop any products that may have resulted from such collaborations. There can be no assurance that these collaborations will be successful. In addition, some of the Company's current partners have certain rights to control the planning and execution of product development and clinical programs, and there can be no assurance that such partners' rights to control aspects of such programs will not impede the Company's ability to conduct such programs in accordance with the schedules currently contemplated by the Company for such programs and will not otherwise impact the Company's strategy. Lengthy Regulatory Process; No Assurance of Regulatory Approvals The testing, manufacturing, labeling, advertising, promotion, export, and marketing, among other things, of the Company's products are subject to extensive regulation by governmental authorities in the United States and other countries. In the United States, pharmaceutical products are regulated by the FDA under the Federal Food, Drug, and Cosmetic Act and other laws, including, in the case of biologics, the Public Health Service Act. At the 7 10 present time, the Company believes that its products will be regulated by the FDA as biologics. Manufacturers of biologics may also be subject to state regulations. The steps required before a biologic may be approved for marketing in the United States generally include (i) preclinical laboratory tests and animal tests, (ii) the submission to the FDA of an Investigational New Drug application ("IND") for human clinical testing, which must become effective before human clinical trials may commence, (iii) adequate and well-controlled human clinical trials to establish the safety and efficacy of the product, (iv) the submission to the FDA of a BLA, (v) FDA review of the BLA, and (vi) satisfactory completion of a FDA inspection of the manufacturing facility or facilities at which the product is made to assess compliance with Good Manufacturing Practices ("GMP"). The testing and approval process requires substantial time, effort and financial resources and there can be no assurance that any approval will be granted on a timely basis, if at all. There can be no assurance that Phase I, Phase II or Phase III testing will be completed successfully within any specific time period, if at all, with respect to any of the Company's potential products. Furthermore, the FDA may suspend clinical trials at any time on various grounds, including a finding that the subjects or patients are being exposed to an unacceptable health risk. The results of the preclinical studies and clinical studies, together with detailed information on the manufacture and composition of the product, are submitted to the FDA in the form of a BLA requesting approval to market the product. Before approving a BLA, the FDA will inspect the facilities at which the product is manufactured, and will not approve the product unless GMP compliance is satisfactory. The FDA may deny a BLA if applicable regulatory criteria are not satisfied, may require additional testing or information, and/or may require postmarketing testing and surveillance to monitor the safety or efficacy of a product. There can be no assurance that FDA approval of any BLA submitted by the Company will be granted on a timely basis if at all. Also, if regulatory approval of a product is granted, such approval may entail limitations on the indicated uses for which it may be marketed. Both before and after approval is obtained, violations of regulatory requirements, including the preclinical and clinical testing process, the BLA review process, or thereafter (including after approval) may result in various adverse consequences, including the FDA's delay in approving or refusal to approve a product, withdrawal of an approved product from the market, and/or the imposition of criminal penalties against the manufacturer and/or license holder. For example, license holders are required to report certain adverse reactions to the FDA, and to comply with certain requirements concerning advertising and promotional labeling for their products. Also, quality control and manufacturing procedures must continue to conform to GMP regulations after approval, and the FDA periodically inspects manufacturing facilities to assess compliance with GMP. Accordingly, manufacturers must continue to expend time, monies and effort in the area of production and quality control to maintain GMP compliance. In addition, discovery of problems may result in restrictions on a product, manufacturer or holder, including withdrawal of the product from the market. Also, new government requirements may be established that could delay or prevent regulatory approval of the Company's products under development. The Company will also be subject to a variety of foreign regulations governing clinical trials and sales of its products. Whether or not FDA approval has been obtained, approval of a product by the comparable regulatory authorities of foreign countries must be obtained prior to the commencement of marketing of the product in those countries. The approval process varies from country to country and the time may be longer or shorter than that required for FDA approval. At least initially, the Company intends, to the extent possible, to rely on foreign licensees to obtain regulatory approval for marketing its products in foreign countries. Under the Orphan Drug Act, the FDA may grant orphan drug designation to drugs intended to treat a "rare disease or condition," which generally is a disease or condition that affects fewer than 200,000 individuals in the United States. Orphan drug designation must be requested before submitting a BLA. After the FDA grants orphan drug designation, the generic identity of the therapeutic agent and its potential orphan use are publicly disclosed by the FDA. Orphan drug designation does not convey any advantage in, or shorten the duration of, the regulatory review and approval process. If a product that has an orphan drug designation subsequently receives FDA approval for the indication for which it has such designation, the product is entitled to orphan exclusivity, i.e., the FDA may not approve any other applications to market the same drug for the same indication, except in certain very limited circumstances, for a period of seven years. In 1994, the Company obtained orphan drug designation for IDEC-C2B8, IDEC-Y2B8 and IDEC-In2B8 from the FDA to treat low-grade B-cell lymphoma. There can be no assurance that any of these compounds will receive orphan exclusivity for the low-grade B-cell lymphoma indication, and it is possible that competitors of the Company 8 11 could obtain approval, and attendant orphan drug exclusivity, for these same compounds for the low-grade B-cell lymphoma indication, thus precluding the Company from marketing its products for the same indication in the United States. In addition, even if the Company does obtain orphan exclusivity for any of its compounds for low-grade B-cell lymphoma, there can be no assurance that competitors will not receive approval of other, different drugs or biologics for low-grade B-cell lymphoma. Although obtaining FDA approval to market a product with orphan drug exclusivity can be advantageous, there can be no assurance that the scope of protection or the level of marketing exclusivity that is currently afforded by orphan drug designation will remain in effect in the future. Additional Financing Requirements and Uncertain Access to Capital Markets The Company has expended and will continue to expend substantial funds to complete the research, development, manufacturing and marketing of its products. The Company may seek additional funding for these purposes through a combination of new collaborative arrangements, strategic alliances, additional equity or debt financings or from other sources. There can be no assurance that such additional funds will be available on acceptable terms, if at all. Even if available, the cost of funds may result in substantial dilution to current shareholders. If adequate funds are not available from operations or additional sources of financing, the Company's business could be materially and adversely affected. Limited Manufacturing Experience The Company has not yet commercialized any therapeutic products. To conduct clinical trials on a timely basis, to obtain regulatory approval and to be commercially successful, the Company must manufacture its products either directly or through third parties in commercial quantities in compliance with regulatory requirements and at an acceptable cost. Although the Company has produced its products in the laboratory, scaled its production process to pilot levels and has the ability to manufacture limited commercial quantities of certain of its products, the Company has not received regulatory approval for such production. The Company anticipates that production of its products in commercial quantities will create technical as well as financial challenges for the Company. The Company has limited experience in manufacturing, and no assurance can be given as to the ultimate performance of the Company's manufacturing facility in San Diego, its suitability for approval for commercial production or the Company's ability to make a successful transition to commercial production. The Company is dependent upon Genentech to fulfill long-term manufacturing demands for its IDEC-C2B8 product and SmithKline Beecham to fulfill all of the manufacturing requirements for IDEC-CE9.1. Genentech is currently constructing a larger manufacturing plant to satisfy such long-term demands. The Company is considering the addition of another manufacturing facility to meet its long-term requirements for additional products under development. Failure by the Company or its strategic partners to establish additional manufacturing capacity on a timely basis would have a material adverse effect on the Company. Patents and Proprietary Rights The Company's success will depend, in large part, on its ability to maintain a proprietary position in its products through patents, trade secret and orphan drug designation. The Company holds one issued and one allowed United States patent, 18 United States patent applications and numerous corresponding foreign patent applications, and has licenses to patents or patent applications of other entities. No assurance can be given, however, that the patent applications of the Company or the Company's licensors will be issued or that any issued patents will provide competitive advantages for the Company's products or will not be successfully challenged or circumvented by its competitors. Moreover, there can be no assurance that any patents issued to the Company or the Company's licensors will not be infringed by others or will be enforceable against others. In addition, there can be no assurance that the patents, if issued, would not be held invalid or unenforceable by a court of competent jurisdiction. Enforcement of the Company's patents may require substantial financial and human resources. Moreover, the Company may have to participate in interference proceedings if declared by the United States Patent and Trademark Office to determine priority of inventions, which typically take several years to resolve and could result in substantial cost to the Company. A substantial number of patents have already been issued to other biotechnology and biopharmaceutical companies. Particularly in the monoclonal antibody field, competitors may have filed applications for or have been issued patents and are likely to obtain additional patents and proprietary rights relating to products or processes competitive with or similar to those of the Company. To date, no consistent policy has emerged regarding the breadth of claims allowed in biopharmaceutical patents, however, patents may issue with claims that conflict with the Company's 9 12 own patent filings or read on its own products. There can be no assurance that patents do not already exist in the United States or in foreign countries or that patents will not be issued that would entail substantial costs to challenge and that, if unsuccessfully challenged, would have a material adverse effect on the Company's ability to market its products. Specifically, the Company is aware of several patents and patent applications which may affect the Company's ability to make, use and sell its products. Accordingly, the Company expects that commercializing monoclonal antibody-based products may require licensing and/or cross-licensing of patents with other companies in this field. There can be no assurance that the licenses, which might be required for the Company's processes or products, would be available, if at all, on commercially acceptable terms. The ability to license any such patents and the likelihood of successfully contesting infringement or validity of such patents are uncertain and the costs associated therewith may be significant. If the Company is required to acquire rights to valid and enforceable patents but cannot do so at a reasonable cost, the Company's ability to manufacture or market its products would be materially adversely affected. The owners, or licensees of the owners, of these patents may assert that one or more of the Company's products infringe one or more claims of such patents. If legal action is commenced against the Company to enforce any of these patents and the plaintiff in such action prevails, the Company could be prevented from practicing the subject matter claimed in such patents. In such event or under other appropriate circumstances, the Company may attempt to obtain licenses to such patents. However, no assurance can be given that any owner would license the patents to the Company at all or on terms that would permit commercialization of the Company's products. An inability to commercialize such products could have a material adverse effect on the Company's operations and ability to pursue its long-term objectives. Limited Sales and Marketing Experience Commercialization of the Company's products is expensive and time-consuming. The Company has adopted a strategy of pursuing collaborative agreements with strategic partners that provide for co-promotion of certain of the Company's products. In the event that the Company elects to participate in co-promotion efforts in the United States or Canada, and in those instances where the Company has retained exclusive marketing rights in specified territories, the Company will need to build a sales and marketing capability in the targeted markets. The Company currently has a limited marketing staff and no sales personnel. There can be no assurance that the Company will be able to establish a successful direct sales and marketing capability in any or all targeted markets or that it will be successful in gaining market acceptance for its products. To the extent that the Company enters into co-promotion or other licensing arrangements, any revenues received by the Company will be dependent on the efforts of third parties and there can be no assurance that such efforts will be successful. Outside of the United States and Canada, the Company has adopted a strategy to pursue collaborative arrangements with established pharmaceutical companies for marketing, distribution and sale of its products. There can be no assurance that any of these companies or their sublicensees will successfully market, distribute or sell the Company's products or that the Company will be able to establish and maintain successful co-promotion or distribution arrangements. Failure to establish a sales capability in the United States or outside the United States may have a material adverse effect on the Company. History of Operating Losses; Accumulated Deficit The Company has incurred annual operating losses since its inception in 1985. As of September 30, 1996, the Company's accumulated deficit was approximately $85.0 million. The Company anticipates that it will continue to incur operating losses over at least the next one to two years. Such losses have been and will be principally the result of the various costs associated with the Company's research and development, clinical and manufacturing activities. The Company has not generated operating profits from the sale of its products. All revenues to date have resulted from collaborative research, development and licensing arrangements, contract manufacturing arrangements, research grants and interest income. The Company has no products approved by the FDA or any foreign authority and does not expect to achieve profitable operations on an annual basis unless product candidates now under development receive FDA or foreign regulatory approval and are thereafter commercialized successfully. 10 13 Possible Volatility of Stock Price The stock market has from time to time experienced significant price and volume fluctuations that may be unrelated to the operating performance of particular companies. In addition, the market price of the Company's common stock, like the stock prices of many publicly traded biotechnology companies, has been highly volatile. Announcements of technological innovations or new commercial products by the Company or its competitors, developments or disputes concerning patent or proprietary rights, publicity regarding actual or potential medical results relating to products under development by the Company or its competitors, regulatory developments in both the United States and foreign countries, public concern as to the safety of biotechnology products and economic and other external factors, as well as period-to-period fluctuations in financial results may have a significant impact on the market price of the Company's common stock. It is likely that, in some future quarter, the Company's operating results will be below the expectations of public market analysts and investors. In such event, the price of the Company's common stock would likely be materially adversely affected. Uncertainties Regarding Health Care Reimbursement and Reform The future revenues and profitability of biopharmaceutical companies as well as the availability of capital may be affected by the continuing efforts of government and third-party payors to contain or reduce costs of health care through various means. For example, in certain foreign markets pricing or profitability of prescription pharmaceuticals is subject to government control. In the United States, there have been, and the Company expects that there will continue to be, a number of federal and state proposals to implement similar government controls. While the Company cannot predict whether any such legislative or regulatory proposals will be adopted, the announcement or adoption of such proposals could have a material adverse effect on the Company's business, financial condition or prospects. The Company's ability to commercialize its products successfully will depend in part on the extent which appropriate reimbursement levels for the cost of such products and related treatment are obtained from governmental authorities, private health insurers and other organizations, such as health maintenance organizations ("HMOs"). Third-party payors are increasingly challenging the prices charged for medical products and services. Also, the trend toward managed health care in the United States and the concurrent growth of organizations such as HMOs, which could control or significantly influence the purchase of health care services and products, as well as legislative proposals to reform health care or reduce government insurance programs may all result in lower prices for the Company's products. The cost containment measures that health care payors and providers are instituting and the effect of any health care reform could materially adversely affect the Company's ability to operate profitably. Product Liability Exposure Clinical trials, manufacturing, marketing and sale of any of the Company's or its strategic partners' pharmaceutical products or processes licensed by the Company may expose the Company to product liability claims. The Company currently carries limited product liability insurance. There can be no assurance that the Company or its strategic partners will be able to continue to maintain or obtain additional insurance or, if available, that sufficient coverage can be acquired at a reasonable cost. An inability to obtain sufficient insurance coverage at an acceptable cost or otherwise protect against potential product liability claims could prevent or inhibit the commercialization of pharmaceutical products developed by the Company or its strategic partners. A product liability claim or recall would have a material adverse effect on the business and financial condition of the Company. Environmental Concerns The Company's research and development involves the controlled use of hazardous materials, chemicals and radioactive compounds. Although the Company believes that its safety procedures for handling and disposing of such materials comply with the standards prescribed by state and federal regulations, the risk of accidental contamination or injury from these materials cannot be completely eliminated. In the event of such an accident, the Company could be held liable for any damages that result and any such liability could exceed the resources of the Company. In addition, disposal of radioactive materials used by the Company in its research efforts may only be made at approved facilities. Approval of a site in California has been delayed indefinitely. The Company currently stores such radioactive materials on site. The Company may incur substantial cost to comply with environmental regulations. 11 14 PART II -- OTHER INFORMATION ITEM 1. LEGAL PROCEEDINGS. None ITEM 2. CHANGES IN SECURITIES. None ITEM 3. DEFAULTS UPON SENIOR SECURITIES. None ITEM 4. SUBMISSION OF MATTERS TO VOTE OF SHAREHOLDERS. None ITEM 5. OTHER INFORMATION. None ITEM 6. EXHIBITS AND REPORTS ON FORM 8-K. (a) Exhibits. The following exhibits are referenced. Exhibit Number Description ------- ----------- 10.1 Lease Agreement between the Company and All Spectrum Services, Inc., dated August 13, 1996. 27.1 Financial Data Schedule (b) Reports on Form 8-K. None 12 15 SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized. IDEC PHARMACEUTICALS CORPORATION Date: November 13, 1996 By: /s/ William H. Rastetter ----------------------- ------------------------ William H. Rastetter Chairman, President and Chief Executive Officer (Principal Executive Officer) Date: November 13, 1996 By: /s/ Phillip M. Schneider ----------------------- ------------------------ Phillip M. Schneider Vice President and Chief Financial Officer (Principal Financial and Accounting Officer) 13
   1
                                  EXHIBIT 10.1

                                 LEASE AGREEMENT

      THIS LEASE AGREEMENT is made as of the 13th day of August, 1996, by and
between, Professors Fund I, L.P., Managing Agent for All Spectrum Services, Inc.
("Landlord") and IDEC Pharmaceuticals Corporation, a California corporation
("Tenant"), who agree as follows:

                             ARTICLE 1. DEFINITIONS

      As used herein, the following terms shall have the following meanings:

      1.1 Premises: Approximately 44,754 square feet, consisting of the entire
Building (which term is defined in Article 2 hereof) located at 3030 Callan
Road, San Diego, California as depicted on Exhibit A attached hereto and
incorporated herein and shall include (1) the exclusive use of the loading dock
shown on Exhibit A and (2) the non-exclusive right to use the Common Areas. The
term "Common Areas" is defined as all areas and facilities outside the Premises
and within the exterior boundary line of the Project that are provided and
designated by Landlord from time to time for the general non-exclusive use of
Landlord, Tenant and other tenants of the Project and their respective
employees, suppliers, shippers, customers and invitees, including parking areas,
trash areas, roadways, sidewalks, walkways, parkways, driveways and landscaped
areas, if any.

      1.2 Property and Project: The real property on which the Building is
located as described in Exhibit "A-1" attached hereto and incorporated herein.
The Project shall consist of the Property, the Building and the building located
at 3020 Callan Road containing approximately 46,172 square feet.

      1.3 Term: Seven (7) years commencing on the Commencement Date.

      1.4 Basic Rent: Shall refer to a monthly amount of $42,516.30 during the
first twelve (12) months of the Lease Term, which is subject to adjustments as
set forth in Article 4 hereof.

      1.5 Initial Direct Operating Expenses: Tenant shall pay its Pro-Rata Share
of Direct Operating Expenses pursuant to Section 4.3 below.

      1.6 Tenant's Pro-Rata Share: 49.22% which percentage represents the
proportion that the number of approximate square feet of the Premises bears to
the total number of square feet of the Project (44,754 square feet/90,926 square
feet in the Project).

      1.7 Commencement Date: November 15, 1996

      1.8 Security Deposit: $42,516.30

      1.9 Permitted Use: Uses allowed by the City of San Diego Scientific
Research Zoning Ordinance in effect as of the date of this Lease as the same may
be modified from time to time, but excluding any retail or restaurant use, and
for no other use or purpose.

      1.10 Tenant's Notice Address: For purposes of Article 19 of this Lease
shall be

            11011 Torreyana Road
            San Diego, CA  92121
            Attn: General Counsel
                  and V.P. Finance


                                       1
   2
      With a copy to:

            Todd Anson, Esq.
            Brobeck, Phleger & Harrison
            550 West C Street
            Suite 1200
            San Diego, CA  92101

      1.11 Lease: Shall collectively refer to this Agreement of Lease together
with the following Exhibits and Addenda, attached hereto and incorporated herein
by this reference:

            Exhibit A:                    Project Site Plan
            Exhibit A-1:                  Property Legal Description
            Exhibit B:                    Rules and Regulations

      1.12 Broker: Landlord and Tenant recognize that John Burnham & Company
represents Tenant and Colliers International represents the Landlord.

                               ARTICLE 2. PREMISES

      Subject to the terms, provisions and conditions of this Lease, Landlord
hereby leases to Tenant, and Tenant hereby takes and hires from Landlord, the
Premises located in Landlord's building located at 3030 Callan Road, San Diego,
California ("Building"). The location of the Building is more particularly shown
on the attached Exhibit A.

                                 ARTICLE 3. TERM

      3.1 Term: The term of this Lease ("Term") shall be for the period
specified in Section 1.3 hereof plus any fraction of a calendar month between
the Commencement Date (hereinafter defined) and the first day of the first full
calendar month of the Term.


      3.2 Commencement Date: The Commencement Date shall be November 15, 1996.
Prior to the Commencement Date, Tenant may enter the Premises to construct the
Tenant Improvements in accordance with Article 6 and for related purposes
authorized by this Lease. Such early entry shall be subject to all of the terms
and conditions of this Lease other than the obligation to pay Rent (as defined
below). Without limiting the foregoing, Tenant shall provide to Landlord prior
to such entry evidence of insurance required to be maintained by Tenant pursuant
to this Lease.

                                 ARTICLE 4. RENT

      From and after the Commencement Date, Tenant agrees to pay Landlord, in
advance, on the first day of each and every calendar month during the Term, the
Basic Rent, together with rental adjustments as defined below. Such rent for any
fraction of a month at the beginning or end of the Term will be prorated and
paid at the Commencement Date. Payment of all such rent and other charges shall
be without offset, deduction or demand, shall be in lawful money of the United
States of America and shall be made to Landlord at the following address, or at
such place Landlord may direct from time to time by written notice to Tenant:

                              Professors Fund I, L.P.
                              as Managing Agent for
                              All Spectrum Services, Inc.
                              Attn: Elizabeth J. Clarquist
                              6170 Cornerstone Court East, Suite 140
                              San Diego, CA 92121

Such rent and other charges shall include the following:


                                       2
   3
      4.1 Basic Rent: Subject to annual increases pursuant to Section 4.2 below,
Tenant agrees to pay Landlord on the first day of each month Basic Rent in the
amount specified in Section 1.4 hereof. Tenant shall pay to Landlord,
immediately upon execution of this Lease (in addition to the Security Deposit
required pursuant to Section 4.7 below), the sum of one (1) month's prepaid
Basic Rent which shall be applied to the first full calendar month of the Term
for which payment of Basic Rent is due. Notwithstanding the foregoing, Landlord
will provide Tenant with ten (10) months of conditional rent abatement such that
Basic Rent shall be abated in full during the second through sixth full calendar
months of the Term and during the thirteenth through seventeenth full calendar
months of the Term ("Free Rent Periods"). During the Free Rent Periods, Tenant
shall be responsible for payment of Direct Operating Expenses Rent. If, during
the Free Rent Periods, Tenant defaults under this Lease and fails to cure such
default within any applicable notice and/or cure period set forth herein, the
Free Rent Period shall thereupon terminate, and Tenant shall immediately
commence paying the full amount of Basic Rent under this Lease. In addition, if
at any time during the Term, Tenant defaults under this Lease and fails to cure
such default within any applicable notice and/or cure period set forth herein
and Landlord terminates this Lease as a result of such uncured default, then the
unamortized portion of all Basic Rent conditionally forgiven during the Free
Rent Periods shall become immediately due and payable upon such termination. The
"unamortized portion" of the conditionally forgiven Basic Rent shall be an
amount equal to (a) the amount of conditionally forgiven Basic Rent multiplied
by (b) a fraction, the numerator of which is 74 months minus the number of
months that Tenant has actually paid the full amount of Basic Rent due to
Landlord, and the denominator of which is 74 months. For example, if Tenant
actually pays the full amount of Basic Rent for 20 months, then Tenant shall
repay to Landlord 72.97 percent of the conditionally forgiven Basic Rent (54
months divided by 74 months).

      4.2 Annual Increase of Basic Rent: Commencing on the first day of the
thirteenth (13th) calendar month immediately following the Commencement Date,
the remaining Term of the Lease shall be divided into consecutive one year
periods (each of which, including the initial twelve (12) calendar months of the
Term, shall be referred to as "Lease Year"). The Basic Rent provided in Section 
4.1 above, shall be increased on the first day of each such Lease Year (i.e., on
the first day of the thirteenth (13th), twenty-fifth (25th), thirty-seventh
(37th), etc., months following the Commencement Date) or, if the Commencement
Date is the first day of a calendar month, on each anniversary of the
Commencement Date ("Adjustment Date"). Each such increase shall be as follows:

--------------------------------------------------------- Months Monthly Basic Rent --------------------------------------------------------- 13 - 24 $44,216.95 --------------------------------------------------------- 25 - 36 $45,985.63 --------------------------------------------------------- 37 - 48 $47,825.05 --------------------------------------------------------- 49 - 60 $49,738.06 --------------------------------------------------------- 60 - 72 $51,727.58 --------------------------------------------------------- 73 - 84 $53,796.68 ---------------------------------------------------------
(i) The increase in Basic Rent provided by this Section 4.2 shall be in addition to Direct Operating Expenses Rent increases provided in Section 4.3. All references in this Lease to Basic Rent shall include any increase in Basic Rent. 4.3 Direct Operating Expenses Rent. (a) From and after the Commencement Date, Tenant agrees to pay to Landlord, as additional rent, Tenant's Pro-Rata Share of Direct Operating Expenses (hereinafter defined) 3 4 incurred by Landlord ("Direct Operating Expenses Rent"). Tenant shall pay to Landlord, Tenant's Direct Operating Expenses Rent pursuant to the following procedures: (i) Landlord shall provide to Tenant a good faith estimate of the annual Direct Operating Expenses and the total amount of annual Direct Operating Expenses Rent with respect to each calendar year of the Term. Landlord shall use reasonable efforts to provide each such estimate to Tenant at least thirty (30) days prior to the end of the calendar year; (ii) Each estimate of total annual Direct Operating Expenses Rent determined by Landlord pursuant to this Section , shall be divided into twelve (12) equal monthly installments. Tenant shall pay to Landlord such monthly installment of Direct Operating Expenses Rent with each monthly payment of Basic Rent pursuant to Section 4.1 above. In the event the estimated amount of Direct Operating Expenses Rent has not yet been determined for any calendar year, Tenant shall pay the monthly installment in the estimated amount determined for the preceding calendar year until the estimate for the current calendar year has been provided to Tenant, at which time Tenant shall, within thirty (30) days following receipt of the notice pay to Landlord any existing shortfall and, thereafter, make the monthly installment payment in accordance with the current estimate; (iii) As soon as reasonably possible following the end of each calendar year of the Term, other than the end of any partial calendar year, but generally no later than sixty (60) days after the end of the calendar year, Landlord shall determine and provide to Tenant a statement of the amount of Direct Operating Expenses actually incurred and the amount of Direct Operating Expenses Rent payable by Tenant with respect to such calendar year, or portion thereof, for any partial calendar year. In the event the amount of such Direct Operating Expenses Rent exceeds the sum of the monthly installments actually paid by Tenant, pursuant to Section 4.3(a)(ii) above, for such calendar year, Tenant shall pay to Landlord within fifteen (15) days after receipt of Landlord's written demand accompanied by the final statement, the difference. In the event the sum of such installments exceeds the amount of Direct Operating Expenses Rent actually due and owing, the difference shall be applied as a credit to Direct Operating Expenses Rent payable by Tenant pursuant to Section 4.3(a)(ii). In no event shall the adjustment of Direct Operating Expenses Rent decrease the amount of Basic Rent due and payable to Landlord under this Lease. In the case of an overpayment for the final full or partial calendar year of the Term, Landlord shall refund the overpayment to Tenant within thirty (30) days after the end of the Term provided that Tenant is not then in default. (b) For purposes of this Section, the following terms shall have the following prescribed meanings: (i) The term "Project" means the Project as defined in Article 1, and the parking areas and other structures and common areas servicing the Project, and the Property upon which the Project and parking area such other structures and common areas are located. (ii) The term "Direct Operating Expenses" as used herein means all actual operating costs and expenses (without overhead or profit to Landlord other than the management fee described below) associated with the operation and maintenance of the Project, exterior landscaping for the Project and such additional facilities as are now in use or in subsequent years may be determined by Landlord to be reasonably desirable. All Direct Operating Expenses shall be determined in accordance with generally accepted accounting principles, consistently applied. Direct Operating Expenses shall include, by way of illustration, but not limitation, the following: (1) Reasonable wages and salaries of all employees in the proportion that such employees are engaged in operating and maintenance or security of the Project, including taxes, insurance and benefits relating thereto, and the reasonable rental value of the Project office. 4 5 (2) All supplies and materials used in operation and maintenance or security of the Project. (3) Actual costs of all utilities (other than electricity not utilized for common areas), including surcharges of the Project (including the cost of water, sewer, gas, power, heating, lighting, air conditioning and ventilating for the Project). (4) Costs of all maintenance and service agreements for the Project, and equipment therein, including, but not limited to, common area utility and maintenance charges (including, but not limited to, assessments or contributions to maintenance associations or special benefit districts); security and energy management services; window cleaning; road, sidewalk, driveways and parking facility maintenance or cleaning; and elevator maintenance. (5) Cost of all insurance relating to the Project, including the cost of casualty and liability insurance applicable to the Project together with Landlord's personal property used in connection therewith, but excluding the cost of any earthquake insurance coverage during the period that the Landlord is Professors Fund I, L.P., as Managing Agent for Spectrum Services, Inc. Any successor Landlord may include the cost of earthquake insurance as a Direct Operating Expense at any time after the first thirty six (36) months of the Term if (a) such successor Landlord is required to maintain earthquake insurance on the Premises by its lender or (b) if it is prudent for owners of similar buildings in the San Diego area to maintain earthquake insurance provided that Tenant's Pro-Rata Share of the premiums for such insurance shall not exceed Twelve Thousand Dollars ($12,000.00) per year during the initial Term. (6) Costs of repairs and general maintenance (excluding repairs and general maintenance paid by proceeds of insurance or by Tenant or other third parties). (7) A management fee for the manager of the Project not to exceed three and one-half percent (3.5%) of Basic Rent. During the initial seven (7) year Term, the management fee shall not exceed $17,856.85 per year. (8) The costs of any additional services not provided to the Project at the Commencement Date but thereafter provided by Landlord in prudent management of the Project or at the direction of or resulting from statutes or regulations, or interpretations thereof, promulgated by any governmental authority in connection with the use or occupancy of the Project that was not applicable when such improvements were originally constructed. (9) The costs of any capital improvements or alterations made to the Project after the Commencement Date that reduce other operating expenses or are required at the direction of or resulting from, statutes, ordinances, rules or regulations, or interpretations thereof, promulgated by any governmental authority in connection with the use or occupancy of the Project that were not applicable when such improvements were originally constructed, such cost thereof to be amortized over the useful life of the improvement in accordance with generally accepted accounting principles, together with interest on the unamortized balance at the rate of ten percent (10%) per annum or such higher rate as may be paid by Landlord on funds borrowed for the purpose of constructing said capital improvements. (10) All taxes, special taxes, assessments and similar impositions levied on the Project (including, without limitation, the land upon which it is located), including, but not limited to, real property taxes and assessments, and personal property taxes and assessments on all personal property of Landlord used in connection with the maintenance and operation of the Project and the reasonable costs incurred by Landlord in contesting, in good faith and by appropriate proceedings the amount or validity of any such tax or assessment. Direct Operating Expenses shall exclude the following: 5 6 (1) Real estate taxes levied on or with respect to any parking garage or facility included in the Project, or any personal property taxes payable by Tenant or by other tenants of the Project; (2) Repairs or other work occasioned by fire, windstorm or other casualty (except for the cost of such repairs or other work that relates to the deductible portion of the insurance policy covering such casualty) or by the exercise of the right of eminent domain; (3) The cost of repairing any defects in the design, materials or workmanship of the Premises, Building or the Project to include foundation and structural components of the walls and roof, unless caused by Tenant in which case Tenant shall be responsible for such cost; (4) Leasing commissions, accountants' or attorneys' fees, costs and disbursement and other expenses incurred in connection with proposals, negotiations, or disputes with tenants or other occupants or prospective tenants or other occupants, or associated with the enforcement of any leases, disputes with contractors, or the defense of Landlord's title to or interest in the Premises or the Project or any part thereof; (5) Costs (including permit, license and inspection fees) incur-red in constructing tenant improvements or decorating, painting or redecorating space for other tenants or other occupants or vacant rentable space; (6) Depreciation and amortization of the Building; (7) Interest on debt or amortization payments on any mortgages or deeds of trust or any other borrowings; (8) Advertising and promotional expenditures; (9) Damage and repairs necessitated by the negligence or willful misconduct of Landlord or Landlord's, employees, contractors or agents; (10) Executive salaries or salaries of service personnel to the extent that such service personnel perform services other than in connection with the management, operation, repair or maintenance of the Premises, the Project or the Common Areas; (11) Costs or fines arising from Landlord's violation of any governmental rule or authority; (12) Costs exceeding those reasonably obtainable by a reasonably prudent owner; (13) Costs arising from Landlord's charitable or political contributions; (14) Costs incurred to test, survey, cleanup, contain, abate, remove or otherwise remedy Hazardous Substances(as defined in Article 37) from the Premises; and (15) Costs to replace the existing coolant in the Building's air conditioning system for the first time during the Term, provided that subsequent replacements shall be included in Direct Operating Expenses. (c) Tenant shall have the right to audit Landlord's books and records relating to Direct Operating Expenses, provided that any audit of Direct Operating Expenses for any calendar year must be commenced within three (3) years after the end of such calendar year and that Tenant may not audit the books and records relating to any calendar year more than once. Tenant shall be solely responsible for all costs and expenses of any audit unless the audit shows that 6 7 Tenant was overcharged for Direct Operating Expenses by more than five percent (5%), in which event Landlord shall pay Tenant's reasonable out of pocket costs and expenses of the audit; provided, however, that Landlord shall have the right to contest the results of the audit in good faith. 4.4 Additional Rent. Tenant shall pay to Landlord as additional rent ("Additional Rent") and without notice, abatement, deduction or set off, all sums, costs and expenses which Tenant, in any of the provisions of this Lease, assumes or agrees to pay, including, but not limited to, tenant improvement work, whether or not any of such sums, costs and expenses are specifically described in this Lease as Additional Rent. In the event of any non-payment of Additional Rent when required under this Lease, the Landlord shall have (in addition to all other rights and remedies) all the rights and remedies provided herein or by law in the case of non-payment of Basic Rent and Direct Operating Expenses Rent. All references in this Lease to Rent shall mean and collectively refer to Basic Rent, Direct Operating Expenses Rent and Additional Rent. 4.5 Late Charges. Tenant's failure to pay Basic Rent and Tenant's Pro-Rata Share of Direct Operating Expenses promptly on the first day of each month may cause Landlord to incur unanticipated costs, the exact amount of which are impractical or extremely difficult to ascertain. Such costs may include, but are not limited to, processing and accounting charges and late charges which may be imposed on Landlord by any ground lease, mortgage or trust deed encumbering the Building. Therefore, if Landlord does not receive any Rent payment within five (5) days after it becomes due, and if such failure continues for three (3) days after notice (which may be given by telephone or facsimile) thereof to Tenant, Tenant shall pay Landlord a late charge equal to five percent (5%) of the overdue amount, provided that if Tenant is more than five (5) days late in the payment of any Rent more than a total of five (5) times during the Term, then such late charge shall apply to any payment of Rent not made within five (5) days after the due date without the requirement of any notice. Notwithstanding the foregoing, only late payments of Basic Rent and Tenant's Pro-Rata Share of Direct Operating Expenses shall be subject to a late charge. The parties agree that such late charge represents a fair and reasonable estimate of the costs Landlord will incur by reason of such late payment. 4.6 Interest. Any amount owed by Tenant to Landlord which is not paid when due shall bear interest at the rate of twelve percent (12%) per annum from the due date of such amount; provided, however, if Tenant pays any Basic Rent or Tenant's Pro-Rata Share of Direct Operating Expenses prior to the date that a late charge becomes due under Section 4.5, then no interest shall be due on such payment. However, interest shall not be payable on late charges to be paid by Tenant under this Lease. The payment of interest on such amounts shall not excuse or cure any default by Tenant under this Lease. If the interest rate specified in this Lease is higher than the rate permitted by law, the interest rate is hereby decreased to the maximum legal interest rate permitted by law. 4.7 Security Deposit. Tenant shall pay to Landlord, immediately upon execution of this Lease, the Security Deposit, which shall be held by Landlord as security for the faithful performance by Tenant of all of the terms, covenants and conditions of this Lease to be kept and performed by Tenant during the Term hereof. If Tenant defaults with respect to any provision of the Lease, including but not limited to, the provisions relating to the payment of Rent, Landlord may (but shall not be required to) use, apply or retain all or any part of the Security Deposit for the payment of any Rent or any other sum in default, or for the payment of any other amount which Landlord may spend or become obligated to spend by reason of Tenant's default or to compensate Landlord for any other loss or damage which landlord may suffer by reason of Tenant's default. If any portion of the Security Deposit is so used or applied, Tenant shall, upon demand therefor, deposit with Landlord cash, in an amount sufficient to restore the Security Deposit to its original amount and Tenant's failure to do so shall be a material breach of this Lease. Landlord shall not be required to keep the Security Deposit separate from its general funds, and Tenant shall not be entitled to interest on the Security Deposit. If Tenant shall fully and faithfully perform every provision of this Lease to be performed by it, the Security Deposit or any balance thereof shall be returned to Tenant at the expiration of the Term, provided that Landlord may retain the Security 7 8 Deposit until such time as any amount due from Tenant in accordance hereof has been determined paid in full. ARTICLE 5. USE 5.1 Permitted Use. Tenant may use the Premises solely for the Permitted Use and for no other use without the written consent of Landlord, which shall not be unreasonably withheld or delayed. 5.2 Compliance with Laws. Tenant shall comply with all laws, ordinances, rules and regulations pertaining to the use of the Premises and/or Building or the Tenant Improvements constructed by Tenant, including all requirements of the Americans With Disabilities Act ("ADA") triggered by construction of the Tenant Improvements and affecting the interior portions of the Premises, except that Landlord agrees to pay fifty percent (50%) of the cost to bring the stairwell within the building located at 3020 Callan Road into compliance with the ADA and Landlord shall comply with the requirements of the ADA affecting the exterior of the Premises up to and including the front door and door threshold as provided in Section 6.1 below. Landlord shall comply with all laws, ordinances, rules and regulations pertaining to the roof, exterior walls or foundation of the Building. Tenant shall not do or permit anything to be done in or about the Premises which will, in any way, obstruct or interfere with the rights of other tenants or occupants of the Building, or injure them, or allow the Premises to be used for any immoral or unlawful purpose, nor shall Tenant cause, maintain or permit any nuisance in, on or about the Premises. Tenant agrees to abide by all reasonable rules and regulations established by Landlord from time to time with respect to the Building provided they do not conflict with this Lease. A copy of the rules and regulations in existence on the date of this Lease is attached hereto as Exhibit "B", but Landlord reserves the right to reasonably and in a non-discriminatory manner amend the rules and regulations at any time by giving notice of amendment to Tenant, if Landlord determines such amendments to be in the best interest of the Building and its tenants. Landlord shall enforce the rules and regulations in a non-discriminatory manner. 5.3 Insurance Use Requirements. Tenant shall neither use nor occupy the Premises in any manner, nor commit or omit any act, which would result in a cancellation or reduction of any insurance or increase in premiums on any insurance policy covering the Premises, or the property or Building. Landlord shall provide notice to Tenant of any changes in insurance as a result of Tenant's act or omission promptly after Landlord learns of such changes, at which time Tenant shall pay any increased insurance costs incurred by Landlord as of such date and shall either modify such use or occupancy to the extent necessary to avoid any increase in premiums or pay any increase in premiums as a result of its use or occupancy. Tenant shall, at its expense, comply with all requirements of any insurer pertaining to use of the Premises and any other requirement which are reasonably necessary for the maintenance of economic and proper fire, liability and other insurance desired to be carried by Landlord. ARTICLE 6. IMPROVEMENTS TO THE PREMISES 6.1 As-Is Condition. Landlord will lease the Premises to Tenant in its "As-Is" condition without any improvements, representations or warranties, except that Landlord shall, at its expense, ensure that all plumbing, electrical and mechanical and other building systems serving the Premises will be in good working order on the Commencement Date and that the Premises will comply with all governmental codes and regulations, including requirements of the ADA, but only to the extent applicable to general use of the Premises and not to any specific use of Tenant, and, except as provided in Section 5.2 above, excluding any requirements affecting the interior of the Premises triggered by construction of the Tenant Improvements (as defined below) by Tenant. Landlord warrants that the HVAC system shall be in good working order for two months after the Commencement Date. 6.2 Tenant Improvements. Except as specifically provided in Section 6.1, any improvements to the Premises required or desired by Tenant ("Tenant Improvements") shall be constructed at Tenant's sole cost and expense, including the cost of space planning, construction 8 9 documents, permits and fees. All plans and specifications for the Tenant Improvements shall be subject to the prior written approval of Landlord, which approval shall not be unreasonably withheld or delayed. Tenant acknowledges and agrees that Landlord agreed to lease the Premises to Tenant at the Basic Rent stated herein and to provide Tenant with the Free Rent Periods based on Tenant's agreement to expend at least a minimum amount of funds on Tenant Improvements. Accordingly, Landlord shall have the right to review and approve a description of the Tenant Improvements to be constructed by Tenant, which approval shall not be unreasonably withheld or delayed. Unless Landlord and Tenant otherwise agree in writing, all Tenant Improvements shall be the property of Landlord. All Tenant Improvements shall be performed in accordance with Sections 7.3 and 7.4 below. Landlord shall receive copies of all building permits relating to the Tenant Improvements. ARTICLE 7. MAINTENANCE, REPAIR AND ALTERATION OF PREMISES 7.1 Maintenance. By taking possession of the Premises, Tenant shall be deemed to have accepted the Premises as being in good, sanitary order, condition, and repair. Tenant shall, at Tenant's sole cost and expense, keep and maintain the interior, non-structural portions of the Premises and every part thereof in good condition and repair, ordinary wear and tear excepted, including, without limitation, maintenance and repair of the heating, ventilation and air conditioning system but excluding any capital improvements that are Landlord's responsibility. Except as specifically provided in Section 6.1 of this Lease, Landlord shall have no obligation whatsoever to alter, remodel, improve, repair, decorate or paint the interior of the Premises or any part thereof, and the parties hereto affirm that Landlord has made no representations to Tenant respecting the condition of the Premises or the Building. 7.2 Repairs. Notwithstanding the provisions of Section 7.1 above, Landlord, as a Direct Operating Expense (subject to the exclusions set forth in Section 4.3 above), shall repair and maintain the water cooling tower serving the Project, fire and life safety systems for the Building, the elevators in the Building, and the exterior and structural portions of the Building (which shall only consist of the roof, the foundation and the exterior walls) in good condition unless such maintenance and repairs are caused in part or in whole by the act, neglect, fault, or omission of any duty by the Tenant, its agents, servants, employees, contractors, licensees or invites, in which case Tenant shall pay Landlord the reasonable cost of such maintenance and repairs. Landlord shall not be liable for any such repairs or to perform any maintenance unless such failure shall persist for an unreasonable time after written notice of the need of such repairs or maintenance is given to Landlord by Tenant. In making such repairs, Landlord shall use reasonable efforts to minimize interference with Tenant's business and the interruption or reduction in services to Tenant. Except as provided in Article 13 hereof, there shall be no abatement of any item of Rent and no liability of Landlord by reason of any injury to or interference with Tenant's business arising from the making of any repairs, alterations, or improvements in or to any portion of the Building or the Premises or in or to fixtures, appurtenances, and equipment therein. Tenant waives the right to make repairs at Landlord's expense under any law, statute, or ordinance now or hereafter in effect. However, if Landlord fails to perform any repairs or maintenance required of Landlord under this Section 7.2, and such failure substantially interferes with Tenant's use and enjoyment of the Premises, then Tenant may provide written notice of such failure and of Tenant's intention to perform such repairs or maintenance. If Landlord does not commence such repairs and maintenance within thirty (30) days after delivery of Tenant's notice, and thereafter use reasonable due diligence to complete such repairs and maintenance, Tenant may complete such repairs and maintenance and may offset the reasonable costs and expenses incurred by Tenant to do so against Tenant's Pro-Rata Share of Direct Operating Expenses to the extent that such costs and expenses exceed the amount that would have been payable by Tenant as its Pro-Rata Share of Direct Operating Expenses had such repairs and maintenance been performed by Landlord. 7.3 Alterations. Tenant shall not make any alteration, addition, or improvement to the Premises (whether structural or non-structure) other than non-structural alterations with a cost of less than $20,000 without the prior written consent of Landlord, which consent will not be unreasonably withheld or delayed. In the event Landlord gives its consent, such consent may be conditioned upon the requirement that Tenant (i) supply to Landlord, plans and specifications which must be 9 10 approved by Landlord in writing prior to commencement of any work; and (ii) provide, prior to the commencement of any work, a lien free completion bond and insurance policies relating to such work in the forms and amounts reasonably satisfactory to Landlord. Any alteration, addition, or improvement for which Landlord gives its written consent shall be accomplished by Tenant in a good and workmanlike manner, in conformity with all applicable laws and regulations and by a contractor reasonably approved by Landlord. Upon completion of any such work, Tenant shall provide to Landlord "as-built" plans, copies, and proof of payment of all labor and materials. Tenant shall pay, when due, all claims for such labor and materials and shall give Landlord at least ten (10) days prior written notice of the commencement of any such work, whether or not Landlord's consent is required. Landlord may enter upon the Premises, in such case, for the purpose of posting appropriate notices, including, but not limited to, notices of non-responsibility. 7.4 Liens. Tenant shall keep the Premises free from any liens arising out of any work performed, materials furnished, or obligations incurred by or for Tenant. In the event that Tenant shall not, within ten (10) days following the imposition of any such lien, cause the same to be released of record by payment or posting of a proper bond, Landlord shall have, in addition to all other remedies provided herein and by law, the right, but not the obligation, to cause the same to be released by such means as it shall deem proper, including payment of or defense against the claim giving rise to such lien. All sums paid by Landlord and all expenses incurred by it in connection therewith shall create automatically an obligation of Tenant to pay an equivalent amount as additional rent, which additional rent shall be payable by Tenant on Landlord's demand with interest at the maximum rate per annum permitted by law until paid. 7.5 Condition on Termination. Upon the expiration, or sooner termination, of the Lease, Tenant shall surrender the Premises to Landlord, broom clean, and in the same condition as received, except for ordinary wear and tear which Tenant was not otherwise obligated to remedy, under any provision of this Lease. Except for Tenant Improvements approved by Landlord and installed in connection with the commencement of this Lease, Landlord may require Tenant to remove any alterations, additions or improvements made by Tenant prior to the termination of the Lease and to restore the Premises to its prior condition (i.e., the condition as of the Commencement Date), all at Tenant's expense; provided, however, that Tenant shall not be required to remove any alterations, additions or improvements consented to by Landlord unless Landlord informs Tenant when it gives consent that Tenant will be required to remove such items. All alterations, additions, and improvements which Landlord does not require Tenant to remove, including all of the Tenant Improvements, shall become Landlord's property and shall be surrendered to Landlord upon termination of the Lease. Except for the Tenant Improvements which shall remain the property of Landlord, Tenant may remove its alterations, additions and improvements to the Premises upon the expiration or earlier termination of the Term provided that Tenant promptly repairs any damage to the Premises caused by such removal. ARTICLE 8. UTILITIES AND SERVICES 8.1 Utilities and Services Furnished by Landlord. Provided Tenant is not in default hereunder, Landlord shall furnish air conditioning and heating services to the Premises. Such services shall be furnished between the hours of 7:00 a.m. and 7:00 p.m., Monday through Friday, and 7:00 a.m. to 1:00 p.m. on Saturday (legal holidays excluded) excepting electricity to the Premises which shall be furnished by Tenant. All of the foregoing utilities and services provided by Landlord shall be included in the Direct Operating Expenses. The common area electrical, air conditioning and heating services furnished by Landlord are not represented by Landlord to be adequate for any purpose other than the Permitted Use. It is acknowledged that the Landlord does not provide an uninterrupted source of electrical power and other services. Under no circumstance shall Landlord be liable to Tenant if any utility service to the Premises and/or Building is interrupted or terminated because of repairs, installations, improvements or causes beyond Landlord's reasonable control, nor shall any such interruption or termination be construed as an eviction (actual or constructive) of Tenant, nor entitle Tenant to an abatement of any item of Rent, nor relieve Tenant from fulfillment of any covenant or condition of this Lease. If any such interruption of utility service is caused by the negligence or willful misconduct of Landlord or its agents, contractors or employees, and if Tenant is not reasonably able to conduct its business from 10 11 the Premises as a result of such interruption for more than three (3) business days, then Tenant shall have the right to full abatement of Rent for so long as such interruption continues after the end of such three (3) business day period and, if Tenant is so prevented from reasonably operating its business for more than one hundred eighty (180) days, Tenant shall have the right to terminate this Lease by delivering written notice of termination to Landlord at any time prior to the date that such utility service is restored. If Tenant so elects to terminate this Lease, such termination shall become effective thirty (30) days after delivery of Tenant's notice to Landlord unless the utility service is restored to the Premises within such thirty (30) day period. Services and utilities (including, but not limited to air conditioning) shall also be provided by Landlord, at an hourly rate established by Landlord from time to time, during additional hours on reasonable notice to Landlord, at Tenant's sole cost and expense, and payable by Tenant, as billed, as Additional Rent. 8.2 Other Utilities and Services. Except as set forth in Sections 8.1 and 8.3, Tenant shall furnish and pay, at Tenant's sole expense, all electrical service inside the Premises, all special electrical and HVAC requirements, telephone, cable and other services which Tenant requires with respect to the Premises. 8.3 Janitorial Services Provided by Tenant. Tenant shall be responsible for janitorial services for the Premises consistent with practices found in similar buildings. ARTICLE 9. TAXES Tenant shall pay, prior to delinquency, all personal property taxes and license fees levied, assessed or imposed by reason of Tenant's use of the Premises, and all taxes on Tenant's personal property located on the Premises. Landlord shall pay all property taxes or assessment with respect to the Building, which shall be included in Direct Operating Expenses. ARTICLE 10. LANDLORD'S RIGHT TO ALTER BUILDING 10.1 Landlord's Right to Alter Building. Landlord reserves and shall, at any and all times, have the right to alter the Building (including, but not limited to, the parking areas and adjoining common areas) or add thereto, and may for the purpose erect scaffolding and all other necessary structures, provided that such actions do not unreasonably interfere with Tenant's use and enjoyment of the Premises. Landlord also reserves the right to install, use, maintain, repair and replace pipes, ducts, conduits, wires and appurtenant meters and equipment for service to other parts of the Building above the ceiling surfaces, below the floor surfaces, within the walls and in the central core areas, and to relocate any pipes, ducts, conduits, wires and appurtenant meters and equipment which are located within the Premises or outside the Premises, provided that such actions do not unreasonably interfere with Tenant's use and enjoyment of the Premises. ARTICLE 11. SIGNS 11.1 Landlord shall maintain, as a Direct Operating Expense, the monument sign for the Project. Landlord, at its sole cost and expense, shall remove the signage of American Residential Mortgage on the Building prior to the Commencement Date. 11.2 Tenant shall not place or permit to be placed, any sign, advertisement, notice or other similar matter on the doors, windows, exterior walls, roof or other areas of the Premises and/or Building which are open to the view of persons in the common area of the Building or grounds, except in compliance with all applicable legal requirements and with the advance written consent of Landlord, which consent shall not be unreasonably withheld or delayed. If any sign, advertisement, notice or similar matter is improperly placed by Tenant, Landlord shall have the right to remove the same, and Tenant shall be liable for any and all expenses incurred by Landlord by the removal. Any signs, advertisement, notice or similar matter (including, but not limited to, directories and nameplates) approved by Landlord shall be at the sole cost and expense of Tenant, except as otherwise provided. 11 12 ARTICLE 12. LIABILITY INSURANCE AND INDEMNITY 12.1 Tenant Insurance. Tenant, at its own expense, shall provide and keep in force with insurance companies authorized to do business in California having a Best's rating of at least "B+:VII" the following insurance policies: (a) Broad form commercial general liability insurance, or equivalent, written on an occurrence form against liability for bodily injury and property damage arising out of or in connection with the use, occupancy or maintenance by Tenant of the Premises (including, without limitation, personal injury coverage and contractual liability insurance specifically covering liability with respect to the indemnity described in section 12.4 below) in the amount of not less than Three Million Dollars ($3,000,000.00) in respect to injuries or death, and in the amount of not less than Three Hundred Thousand Dollars ($300,000.00) per occurrence in respect to damage to property; (b) Fire insurance with standard form extended coverage endorsement to the extent of at least one hundred percent (100%) of the full insurable value of the Tenant Improvements, other additions, alterations and improvements to the Premises installed at Tenant's expense, and all trade fixtures, fixtures, equipment and other personal property which may, from time to time, be located upon the Premises; and (c) Such other insurance as Tenant or Landlord or any beneficiary of any deed of trust encumbering the Building or the Property of which the Premises are a part, may from time to time, reasonably require, in form, amount and protecting against such risks as would be obtained by a prudent person. Each of the foregoing policies of insurance shall name the Landlord and any mortgagee as an additional insured. Tenant may maintain such insurance as part of blanket policies containing a "per project, per location" endorsement. Landlord makes no representation that the minimum insurance amounts specified above are adequate to protect Tenant, and the amount of insurance obtained by Tenant shall not limit Tenant's liability under this Lease. Tenant shall furnish Landlord with a certificate of such policy and certified copies of all required endorsements prior to taking possession of the Premises or occupying any part thereof and whenever requested shall satisfy Landlord that such policy is in full force and effect. Each policy shall be primary and non-contributing with any insurance carried by Landlord. Each policy shall further provide that it shall not be canceled or altered without thirty (30) days prior written notice to Landlord. 12.2 Landlord Insurance. Landlord shall carry (i) "all risk" property damage insurance with respect to the Building on a full replacement cost basis, (ii) commercial general liability insurance (or equivalent) on an occurrence basis and of the type and in the amounts as Landlord shall deem reasonably appropriate and (iii) such other reasonable and customary insurance with respect to the Building, that Landlord shall deem reasonably appropriate or that is required by Landlord's lender for the Project, including rental loss insurance covering rental losses that would occur if Tenant is entitled to abatement of Rent due to casualty, interruption of utility services and similar events. The cost of any such insurance shall be included in the Direct Operating Expenses. In addition, in the event Tenant fails to provide or keep in force any of the insurance as required pursuant to Section 12.1 above, Landlord, in its discretion, may provide such insurance, in which event, the cost thereof shall be payable by Tenant to Landlord, as Additional Rent on the first day of the calendar month immediately following demand therefor from Landlord. All insurance policies required to be maintained by Landlord shall be issued by insurance companies authorized to do business in California having a Best's rating of at least "B+:VII." 12.3 Waiver of Liability of Landlord. Landlord shall not be liable to Tenant for any injury or damage that may result to any person or property by or from any cause whatsoever (including, without limiting the generality of the foregoing, injury or damage due to water leakage of any character from the walls, basement or other portion of the Premises or Building or caused by gas, fire, oil, electricity or any use whatsoever, in, on or about the Premises or Building or any part 12 13 thereof, or theft), other than injury or damage resulting from the negligence or willful misconduct of Landlord or its agents, employees or contractors or Landlord's breach of this Lease. 12.4 Indemnity by Tenant of Landlord. Tenant agrees to indemnify, hold Landlord and its agents, employees, affiliates, officers, directors and shareholders (collectively, the "Indemnitees") harmless from and defend Landlord and the Indemnitees against any and all claims, damages, costs, expenses (including attorneys' fees and costs incurred in connection therewith or to enforce this indemnity obligation) and liabilities for any injury or damage to any person or property whatsoever (i) occurring in, on or about the Premises or any part thereof, or (ii) occurring in, on or about any the Property (including, without prejudice to the generality of the term "Property", passageways or hallways) the use of which Tenant may have in conjunction with other tenants of the Building, when such injury or damage shall be caused in part or in whole, by the act, negligence or fault of, or omission of any duty with respect to the same by Tenant, its agents, servants or employees, except to the extent caused by the negligence or willful misconduct of Landlord or its agents, employees or contractors or by Landlord's breach of this Lease. In case any action, suit or proceeding is brought against Landlord and/or the Indemnitees for which Tenant is required to provide indemnity pursuant to this Section , Tenant, upon Landlord's request and at Tenant's sole cost and expense, will resist and defend such action, suit or proceeding or cause the same to be resisted and defended by counsel designated by Tenant and approved by Landlord, or counsel designated by the insurer whose policy covers the cost, claim, damage or liability. At Landlord's election, Landlord may select and employ counsel to resist and defend the action, suit or proceeding and Tenant will reimburse Landlord for any legal fees or costs incurred by Landlord in connection therewith. The obligations of Tenant under this section will survive the expiration or any termination of this Lease. 12.5 Waiver of Subrogation. Landlord and Tenant agree to cause the insurance companies issuing their respective property insurance to waive any subrogation rights that those companies may have against Tenant or Landlord, respectively, as long as the insurance is not invalidated by the waiver. If the waivers of subrogation are contained in their respective insurance policies, Landlord and Tenant waive any right that either may have against the other on account of any loss or damage to their respective property to the extent that the loss or damage is insured under their respective insurance policies. ARTICLE 13. DAMAGE OR DESTRUCTION AND CONDEMNATION 13.1 Duty to Restore. In the event the Premises or the Building of which the Premises are a part are destroyed or damaged as a result of any cause, then Landlord shall forthwith repair the same, provided the extent of the destruction or damage can be repaired within one (1) year after the date of damage or destruction and the insurance proceeds available to Landlord are adequate to complete such repairs. In the event the destruction of the Premises or the Building is to an extent that the estimated repair period exceeds one (1) year from the date of damage or destruction or such available insurance proceeds are not adequate, then Landlord shall have the option (i) to repair or restore such damage and this Lease will continue in full force and effect, except that Tenant shall be entitled to a proportionate reduction of Basic Rent while such repairs are being made, such proportionate reduction to be based upon the extent to which the making of such repairs shall materially interfere with the business carried on by Tenant in the Premises (provided, however, that if the damage is due to the fault or neglect of Tenant or its employees, there shall be no abatement of Basic Rent); or (ii) give notice to Tenant at any time within sixty (60) days after such damage terminating this Lease as of the date of the damage or destruction. In the event of giving such notice, this Lease shall expire and all interest of the Tenant in the Premises shall terminate as of the date of the damage or destruction. Tenant shall have the right to terminate this Lease upon written notice delivered to Landlord no later than sixty (60) days after the date of such damage if (i) the estimated repair period exceeds one (1) year from the date of the damage or (ii) during the last twelve (12) months of the Term of this Lease, such estimated repair period exceeds ninety (90) days. In addition, Tenant may terminate this Lease if any such repairs are not completed within one (1) year after the date of the damage by delivering written notice of termination to Landlord at any time prior to completion of the repairs, in which event this Lease 13 14 shall terminate unless Landlord completes the repairs within thirty (30) days after the date Tenant's termination notice is delivered to Landlord. 13.2 Exclusions from Duty to Restore. Notwithstanding anything to the contrary contained in this Article: (a) Landlord shall not have any obligation whatsoever to repair, reconstruct or restore the Premises when the damage resulting from any casualty covered under this article occurs during the last twelve (12) months of the term of this Lease or any extension thereof. (b) Landlord shall not be required to repair any damage by fire or other cause, or to make any repairs or replacements of any panels, decoration, office fixtures, railings, floor covering, partitions, or any other property installed in the Premises by Tenant. (c) Tenant shall not be entitled to any compensation or damages from Landlord for loss of the use of the whole or any part of the Premises. Tenant's personal property or any inconvenience or annoyance occasioned by such damage, repair, reconstruction or restoration. 13.3 Total Taking. If the whole of the Premises or so much thereof as to prevent Tenant from reasonably operating its business within the balance of the Premises shall be taken under power of eminent domain, this Lease shall automatically terminate as of the date of such condemnation, or as of the date possession is taken by the condemning authority, whichever is earlier. If a partial taking prevents Tenant from reasonably operating its business within the balance of the Premises, Tenant shall give written notice thereof to Landlord within thirty (30) days of the taking. No award of any partial or entire taking shall be apportioned and Tenant hereby assigns to Landlord any award which may be made in such taking or condemnation, together with any and all rights of Tenant now or hereafter arising in or to the same or any part thereof; provided, however, Tenant shall be entitled to any award made to Tenant for the taking of personal property and fixtures belonging to Tenant or for Tenant's relocation costs or business interruption compensation. 13.4 Partial Taking. In the event of a partial taking of the Premises which does not result in a termination of this Lease pursuant to Section 13.3, rent shall be abated, effective as of the date possession of the Premises is required to be surrendered, in proportion to the part of the Premises that Tenant cannot reasonably use to operate its business within the Premises. Landlord shall restore the portion of the Premises remaining usable to as near its former condition as reasonably possible using that portion of the condemnation award attributable to such restoration costs. 13.5 Temporary Taking. No temporary taking of the Premises and/or of Tenant's rights therein or under this Lease shall terminate this Lease or give Tenant any right to any abatement of rent hereunder. Any award made to Tenant by reason of any such temporary taking shall belong entirely to Tenant and Landlord shall not be entitled to share therein. 13.6 Sale. A sale by Landlord to any authority having the power of eminent domain, either under threat of condemnation or while condemnation proceedings are pending, shall be deemed a taking under the power of eminent domain for all purposes under this Article 13. 13.7 Waiver. Tenant hereby waives any right under any statutes, ordinances, court decisions or other application law, whether existing now or in the future, to terminate this Lease following any taking, condemnation, damage or destruction of the Premises and/or the Building. ARTICLE 14. DEFAULT BY TENANT 14.1 Remedies Upon default. Tenant agrees that (i) if Tenant fails to make a payment of any item of Rent and such failure continues for a period of five (5) days after written notice thereof; or (ii) if Tenant fails to faithfully perform or observe any other agreement and such failure continues for a period of thirty (30) days after written notice thereof; unless Tenant commences to cure the 14 15 failure within thirty (30) days and diligently and continuously proceeds to complete the cure as soon as reasonably possible, but in no event later than ninety (90) days, or (iii) if the Premises be vacated or abandoned; or (iv) if Tenant makes a general assignment for the benefit of its creditors and becomes unable to pay its debts as they become due in the normal course, or shall file a petition for bankruptcy or other reorganization, liquidation, dissolution or similar relief; or (v) a proceeding is filed against Tenant seeking any relief mentioned in (iv) above unless the same is dismissed within sixty (60) days; or (vi) a trustee, receiver or liquidator shall be appointed for Tenant or a substantial part of its property where possession is not restored to Tenant within sixty (60) days; or (vii) if Tenant's lease interest is sold under execution, then any such events shall constitute a breach of this Lease and Landlord may, at Landlord's option, exercise any or all rights available to a Landlord under the laws of the State of California, including, without limitation, the right to do any of the following: (a) Terminate the Lease and recover: (i) The worth at the time of award of unpaid rent and other charges which had been earned at the time of such termination; plus (ii) The worth at the time of the award of the amount by which the unpaid rent and other charges which would have been earned after termination until the time of award exceeds the amount of such rental loss which Tenant proves could have been reasonably avoided; plus (iii) The worth at the time of award of the amount by which the unpaid rent and other charges for the balance of the Term of this Lease after the time of award exceeds the amount of such rental loss which Tenant proves reasonably could be avoided; plus (iv) Any other amount necessary to compensate Landlord for all the detriment proximately caused by Tenant's failure to perform its obligation under this Lease or which in the ordinary course of things would be likely to result therefrom, including but not limited to the cost of restoring the Premises to the condition required in Article 7.5 of this Lease; plus (v) At Landlord's election, such other amounts in addition to or in lieu of the foregoing as may be permitted from time to time by applicable law. (b) Utilize the remedy described in California Civil Code Section 1951.4 (Landlord may continue this Lease in effect after Tenant's breach and abandonment and recover rent as it becomes due, if Tenant has the right to sublet or assign, subject only to reasonable limitations), as follows: (i) Landlord can continue this Lease in full force and effect without terminating Tenant's right of possession, and Landlord shall have the right to collect rent and other monetary charges when due and to enforce all other obligations of Tenant hereunder. Landlord shall have the right to enter the Premises to do acts of maintenance and preservation of the Premises, to make alterations and repairs in order to relet the Premises, and/or to undertake other efforts to relet the Premises. Landlord may also remove personal property from the Premises and store the same in a public or private warehouse at Tenant's expense and risk. No act by Landlord permitted under this paragraph shall terminate this Lease unless a written notice of termination is given by Landlord to Tenant or unless the termination is decreed by a court of competent jurisdiction. (ii) In furtherance of the remedy set forth in this Section , Landlord may relet the Premises or any part thereof for Tenant's account, for such term (which may extend beyond the Lease term), at such rent, and on such other terms and conditions as Landlord may deem advisable in its sole discretion. Tenant shall be liable immediately to Landlord for all costs Landlord incurs in reletting the Premises. Any rents received by Landlord from such reletting shall be applied to the payment of: (a) first, any indebtedness other than rent due hereunder from Tenant to Landlord; (b) second, the costs of such reletting, including brokerage and attorney's fees and the 15 16 cost of any alterations and repairs to the Premises; and (c) third, the payment of rent due and unpaid hereunder. Any remainder shall be held by Landlord and applied in payment of future amounts as the same become due and payable hereunder. In no event shall Tenant be entitled to any excess rent received by Landlord after a breach of this Lease by Tenant and the exercise of Landlord's remedies hereunder. If the rent from such reletting during any month is less than the rent payable hereunder, Tenant shall pay such deficiency to Landlord immediately upon demand. 14.2 Worth at the Time of Award. As used in Section 14.1(a)(i) and 14.1(a)(ii) above, the "worth at the time of award" shall be computed by allowing interest at the lesser of twelve percent (12%) per annum or the maximum rate permitted by law. As used in Section 14.1(a)(iii), above, the "worth at the time of award" shall be computed by discounting such amount at the discount rate of the Federal Reserve Bank of San Francisco at the time of award plus one percentage point per annum. 14.3 Notification of Reletting. In the event Landlord terminates this Lease pursuant to Section 14.1(a) above, and Tenant has made an advance payment of rent as defined in California Civil Code Article 1951.7, and Tenant has requested in writing that Landlord notify it of any initial reletting of Premises, then and only then must Landlord notify Tenant pursuant to California Civil Code Article 1951.7(c) that the Premises have been relet. 14.4 Right of Landlord to Re-Enter. In the event of any termination of this Lease, Landlord shall have the immediate right to enter upon and repossess the Premises, and any personal property of Tenant may be removed from the Premises and stored in any public warehouse at the risk and expense of Tenant. 14.5 Landlord's Right to Pursue Other Remedies. In the event of any breach of this Lease, Landlord may pursue any of the foregoing remedies, and Landlord may consecutively or concurrently therewith pursue any other remedy or enforce any right to which Landlord may be entitled by law. 14.6 Landlord's Default. Landlord's failure to perform any of its obligations under this Lease shall constitute a default by Landlord under this Lease if the failure continues for thirty (30) days after written notice of the failure from Tenant to Landlord. If the required performance cannot be completed within thirty (30) days, Landlord's failure to perform shall not constitute a default if Landlord undertakes to cure the failure within such thirty (30) day period and thereafter diligently pursues such cure to completion. ARTICLE 15. SUBORDINATION 15.1 This Lease and the leasehold estate created hereby are and shall be, at the option and upon written declaration of Landlord, subject, subordinate and inferior to the lien and estate of any liens, trust deeds and encumbrances, and all renewals, extensions or replacements thereof, now or hereafter imposed by Landlord upon the Premises or any part of the Building. Landlord hereby expressly reserves the right, at its option and declaration, to place liens, trust deeds and encumbrances upon and against the Premises and/or any part thereof and/or the Building, superior in lien and effect to this Lease and the estate created hereby. The execution by Landlord and the recording in the Office of the County Recorder of the county in which the Premises are situated, of a declaration that this Lease and leasehold estate are subject, subordinate and inferior to any lien, trust deed or encumbrance placed by Landlord upon or against the Premises, and/or any part thereof and/or the Building, shall, of and by itself (in favor of any lienor, mortgagee, beneficiary, trustee or title insurance company insuring the interest of any such person) and without further notice to or act or agreement of Tenant, make this Lease and the estate created hereby subject, subordinate and inferior thereto. Notwithstanding the foregoing, Tenant agrees, on request of Landlord, to forthwith execute and acknowledge any reasonable subordination agreement or other documents required to establish of record the priority of any such encumbrance over this Lease, and also to execute and deliver to Landlord, promptly on request, any reasonable estoppel certificate or other statement to be furnished to any prospective purchaser or lender against the Premises stating the matters specified in Article 27 hereof. 16 17 15.2 In the event any proceedings are brought for foreclosure, or in the event of the exercise of the power of sale under any mortgage or deed of trust made by the Landlord covering the Premises, the Tenant shall attorn to the purchaser upon any such foreclosure or sale and recognize such purchaser as the Landlord under this Lease. Tenant's obligations to provide a subordination agreement or other documents pursuant to Section 15.1 or to attorn to the purchaser under this Section 15.2 shall be conditioned upon the lender executing and delivering to Tenant a commercially reasonable non-disturbance agreement. 15.3 The provisions of this Article to the contrary notwithstanding, and so long as Tenant is not in default hereunder, this Lease shall remain in full force and effect for the full term hereof. 15.4 Landlord agrees to use reasonable best efforts to obtain and deliver to Tenant a commercially reasonable non-disturbance agreement from any lender with a lien on the Building senior to this Lease. ARTICLE 16. ATTORNEY'S FEES In case any suit shall be brought for any unlawful detainer of the Premises, for the recovery of any Rent due under this Lease, or because of the breach or alleged breach of any other covenant herein contained on the part of either party to be kept or performed, the prevailing party shall recover from the non-prevailing party all reasonable costs and expenses incurred therein, including reasonable attorney's fees, and reasonable attorney's fees and expenses incurred in enforcing any judgment. Further, if for any reason Landlord consults legal counsel or otherwise incurs any costs or expenses as a result of its rightful attempt to reasonably enforce the provisions of this Lease, even though no litigation is commenced, or if commenced is not pursued to final judgment, Tenant shall be obligated to pay to Landlord, in addition to all other amounts for which Tenant is obligated hereunder, all of Landlord's reasonable costs and expenses incurred in connection with any such acts, including reasonable attorneys' fees. ARTICLE 17. ASSIGNMENT AND SUBLETTING 17.1 Landlord's Consent Required. The purpose of this Lease is to transfer possession of the Premises to Tenant for Tenant's personal use and Tenant has not entered into this Lease for the purpose of obtaining the right to convey the leasehold to others. The ability of Tenant to assign or sublet the Premises is subsidiary and incidental to the underlying purpose of this Lease. Tenant will not, either voluntarily or by operation of law, assign, transfer, mortgage, pledge, hypothecate or encumber this Lease or any interest herein, and will not sublet the Premises or any part thereof or any right or privilege appurtenant thereto, or allow any other person (the employees, agents, servants and invitees of Tenant excepted) to occupy or use the Premises or any portion thereof, without the prior written consent of Landlord, which consent will not be unreasonably withheld or delayed. If Tenant is a partnership or corporation, any cumulative transfer of more than fifty percent (50%) of the partnership interests, or fifty percent (50%) of the voting stock (unless Tenant's stock is publicly traded on a nationally recognized exchange), as the case may be, will be deemed to be an assignment by Tenant of this Lease which assignment requires the prior written consent of Landlord. Tenant shall have the right without Landlord's consent (but with prior written notice to Landlord) to enter into an assignment or sublease with any entity controlling or controlled by Tenant or any entity succeeding to substantially all of the assets of Tenant as a result of a consolidation or merger, or any entity to which all or substantially all of the assets of Tenant have been sold, provided that on or before the effective date of any such transfer, the assignee, sublessee or transferee executes and delivers to Landlord an assignment and assumption agreement in form and content satisfactory to Landlord and executed by Tenant and such assignee, sublessee or transferee, as the case may be and that the assignee, sublessee or transferee has a net worth on the date of the assignment equal to or greater than Tenant's net worth on the date of this Lease. Landlord's consent shall not be required for any transfer of the stock of Tenant so long as Tenant's stock is publicly traded on a nationally recognized exchange. 17 18 Any transfer or subletting attempted or concluded without Landlord's prior written consent will be void and will constitute a default under this Lease. Consent by Landlord to any transfer (including, but not limited to, an assignment or subletting), shall be limited to the particular transfer approved by Landlord and shall not be deemed to be Landlord's consent to any subsequent transfer. Tenant acknowledges Landlord shall have no obligation to sublessees and Tenant agrees to be responsible for such parties' compliance with all rules, regulations, and other covenants. 17.2 Landlord's Election. Tenant's request for consent to any transfer, described in Section 17.1 above must be accompanied by a written statement setting forth the details of the proposed transfer, including the name, type of business and financial condition (supported by financial statements) of the prospective transferee, financial details of the proposed transfer (e.g. the terms of the transaction, the rent and security deposit payable under any assignment or sublease), copies of all agreements and other writings pertaining in any way to the proposed transfer. Tenant, in addition to the foregoing information which must be delivered to Landlord at the time Tenant requests Landlord's consent to the proposed transfer, shall deliver to Landlord any additional information concerning the proposed transfer or prospective transferee as Landlord may reasonably request. Landlord will have the right (i) to reasonably withhold consent; or (ii) to grant written consent to the transfer. Within fifteen (15) business days after submission of all required information for the request for consent of proposed transfer, Landlord shall give notice to Tenant of its election under this Section . If Landlord fails to give such notice, Landlord shall be presumed to have denied Tenant's request for such proposed transfer. 17.3 Withholding Consent. Under Section 17.2(i), Landlord may withhold its consent to the proposed transfer on any reasonable ground. Such reasonable grounds shall include, without limitation, any one or more of the following: (i) That the prospective transferee's financial condition is or may become insufficient to support all of the financial and other obligations of this Lease; (ii) That the use to which the Premises will be put by the prospective transferee is inconsistent with the terms of this Lease or other existing leases or is otherwise not suitable for a first class office building; (iii) That the nature of the prospective transferee's proposed or likely use of the Premises would involve any increased risk of the use, release or mishandling of hazardous materials; (iv) That the prospective transferee is not likely to conduct on the Property a business of a quality substantially equal to that conducted by other typical businesses operating within the Scientific Research Zoning Ordinance; (v) That Landlord has not received assurances acceptable to Landlord in its sole discretion that all past due amounts owing from Tenant to Landlord (if any) will be paid and all other defaults on the part of Tenant (if any) will be cured prior to the effectiveness of the proposed transfer. If Landlord withholds its consent to the proposed transfer pursuant to Section 17.2(i), and if Tenant shall so request in writing, Landlord shall provide to Tenant a statement of the basis on which Landlord denied its consent within a reasonable time after the receipt of Tenant's notice. Tenant acknowledges and agrees that each of the rights of Landlord in the event of proposed transfer set forth in this Article is a reasonable restriction on transfer for purposes of California Civil Code Section 1951.4. 17.4 Tenant's Obligations Continuing. No transfer within the scope of this Article, whether with or without Landlord's consent, will release Tenant or change Tenant's primary liability to pay Rent and to perform all other obligations of Tenant under this Lease. Landlord's acceptance of Rent from any other person is not a waiver of any provision of this Section . If Tenant's transferee defaults under this Lease, Landlord may proceed directly against Tenant 18 19 without pursuing remedies against the transferee. Landlord may consent to subsequent assignments or modifications of this Lease by Tenant's transferee, without notifying Tenant or obtaining its consent, and such action will not relieve Tenant of its liability under this Lease. 17.5 Excess Rental. With respect to any sublease entered into by Tenant with Landlord's consent as herein provided, if the rent and other compensation paid by the subtenant to Tenant under such sublease, and all agreements and other instruments pertaining in any way thereto, exceeds the Rent being paid by Tenant to Landlord computed on a square foot basis (i.e., the amount by which the rent and other compensation being paid by the subtenant to Tenant exceeds the Rent being paid by Tenant to Landlord under this Lease for each square foot leased by such subtenant) then Landlord will be entitled to fifty percent (50%) of such excess ("Excess Rent") and Tenant will pay to Landlord such Excess Rent within five (5) days after receipt by Tenant of the same. If Tenant receives any fee, bonus or other payment (whether payable in one or more installments) from any assignee or sublessee as partial consideration for the making of such sublease or assignment ("Bonus Payment"), fifty percent (50%) of such Bonus Payment shall be paid over to Landlord as additional rent hereunder. Notwithstanding the foregoing, any Excess Rent or Bonus Payment shall be determined after deducting the amount of out-of-pocket expenses actually incurred by Tenant for reasonable and customary brokerage commissions, attorneys' fees, tenant improvements, monetary and non-monetary lease concessions (including free rent) or other expenses in connection with sublease or assignment provided Tenant delivers sufficient evidence of such expenses to Landlord. 17.6 Security Interest. Tenant immediately and irrevocably assigns to Landlord as security for Tenant's obligations under this Lease all rent from any subletting of all or a part of the Premises as permitted by this Lease, and Landlord as assignee and as attorney-in-fact for Tenant, or a receiver for Tenant appointed on Landlord's application, may collect such rent and apply it toward Tenant's obligations under this Lease; except that, until the occurrence of an event of default by Tenant, Tenant will have the right to collect such rent. 17.7 Transfer Fee. In the event Tenant requests Landlord's consent to a sublease or assignment hereunder, Tenant shall reimburse Landlord for all attorney's fees incurred by Landlord in connection with review and preparation of documents in connection with such sublease or assignment and will pay Landlord a reasonable fee, not to exceed $250, for Landlord's processing of documents necessary to the giving of such consent and/or assumption by the assignees. ARTICLE 18. PARKING Landlord shall maintain approximately 3.25 parking spaces per 1,000 rentable square feet within the Project, and Tenant shall have the right, in connection with its use and occupancy of the Premises, to use its Pro-Rata Share of such spaces on a non-reserved basis. Other than payments of Rent required hereunder, Tenant shall have the right to use such parking spaces at no additional cost. Tenant may elect to have Landlord stripe five (5) visitor parking spaces and seven (7) car pool spaces directly in front of the north entrance to the Building at Landlord's expense. Such striped parking spaces will be part of Tenant's Pro-Rata Share of parking spaces. ARTICLE 19. NOTICES 19.1 Manner of Service. All notices, demands or requests from one party to another shall be personally delivered or sent by mail, certified or registered, postage prepaid, to the address stated in this Article. 19.2 Notice of Landlord. All such notices, demands or requests from Tenant to Landlord shall be given to Landlord, addressed as follows: Professors Fund I, as Managing Agent for All Spectrum Services, Inc. Attn.: Elizabeth J. Clarquist 6170 Cornerstone Court East, Suite 140 San Diego, CA 92121 19 20 with copy to: Luce, Forward, Hamilton & Scripps LLP Attn.: David M. Hymer 600 West Broadway, 26th Floor San Diego, CA 92101 Landlord may change its address for notices by giving written notice of such change to Tenant in the manner provided by this Article 19. 19.3 Notice to Tenant. All such notices, demands or requests from Landlord to Tenant shall be given to Tenant, addressed, if prior to the Commencement Date, to Tenant's Notice Address and, after the Commencement Date, to the Premises. ARTICLE 20. HOLDING OVER BY TENANT Tenant agrees upon the expiration or termination of this Lease, immediately and peaceably to yield up and surrender the Premises, notice to quit or vacate is hereby expressly waived. Tenant shall be liable to Landlord for any and all damages incurred by Tenant as the result of any failure by Tenant, timely, to surrender possession of the Premises as required herein. If Tenant shall hold over after the expiration of this Lease for any cause, such holding over shall be deemed a tenancy at sufferance or, at the sole discretion of Landlord, a tenancy from month-to-month only, in which event such month-to-month tenancy shall be upon the same terms, conditions and provisions as in this Lease contained, 125% of the monthly Rent as was in effect immediately prior to the termination. ARTICLE 21. WAIVER One or more waivers by Landlord of any breach of any covenant or condition shall not be construed as a waiver of a subsequent or continuing breach of the same or of any covenant or condition, and the consent or approval by Landlord to any act by Tenant requiring Landlord's consent or approval shall not be deemed to waive or render unnecessary Landlord's consent or approval to or of any subsequent act. No waiver of any provision of this Lease shall be deemed to have been made, unless it be in writing and signed by the party to be charged therewith. ARTICLE 22. LANDLORD'S RIGHT OF ENTRY Landlord and its agents may enter upon the Premises at any time in cases of emergency and otherwise at any reasonable time during normal business hours after reasonable notice to Tenant and with Tenant's supervision to post such notices as Landlord may deem necessary to exempt Landlord and Landlord's title from responsibility on account of any work or repairs done by Tenant upon or in connection with the Premises; to inspect and examine the Premises and see that the covenants hereof are being kept and performed; to make such repairs, additions or improvements as Landlord shall deem necessary; or, to exhibit the Premises to prospective lessees or purchasers thereof provided that Landlord shall use reasonable efforts not to unreasonably interfere with Tenant's business operations. ARTICLE 23. TIME OF THE ESSENCE Time is expressly declared to be of the essence of this Lease, and of all covenants and conditions herein contained. ARTICLE 24. SUCCESSORS AND ASSIGNS The covenants and conditions herein contained shall, subject to the provisions of Article 17 and this Article, apply to and bind the heirs, successors, executors, administrators and assigns of the respective parties hereof. If this Lease is signed by more than one person as Tenant, their obligation shall be joint and several. 20 21 Landlord may freely and fully assign its interest hereunder. The term "Landlord" shall mean only the owner at the time in question of the Building or of a lease of the Building, so that in the event of any transfer or transfers of title to the Building or of Landlord's interest in a lease of the Building, the transferor shall be and hereby is relieved and freed of all obligation of Landlord under this Lease accruing after such transfer, and it shall be deemed, without further agreement, that such transferee has assumed and agreed to perform and observe all obligations of Landlord herein during the period it is the holder of Landlord's interest under this Lease. Tenant shall attorn to and recognize as its landlord under this Lease any transferee of the Building or Landlord's interest hereunder. In any event, Tenant shall look only to Landlord's estate and property in the Building and the land on which it is located for satisfaction of Tenant's remedies for the collection of a judgment (or other judicial process) requiring the payment of money by Landlord in the event of any default by Landlord hereunder, and no other property or assets of Landlord or its officers, directors, agents, employees, affiliates, partners or principals, disclosed or undisclosed, shall be subject to levy, execution or other enforcement procedure for the satisfaction of Tenant's remedies under or with respect to this Lease, the relationship of Landlord and Tenant hereunder or Tenant's use or occupancy of the Premises, and no such parties shall be named in any action or suit by Tenant against Landlord. ARTICLE 25. BUILDING NAME Tenant shall not use the name of the Building or words to that effect in connection with any business on the Premises without the written consent of Landlord. Landlord may change the name of the Building at any time without consent of or notice to Tenant. ARTICLE 26. KEYS Tenant may re-key the Premises at any time provided that Tenant shall provide two (2) copies of each access card and each key to the Premises at the time any re-keying is done. ARTICLE 27. ESTOPPEL CERTIFICATES Tenant agrees, at any time and from time to time, upon not less than five (5) days prior written notice by Landlord, to execute, acknowledge and deliver to Landlord, a statement in writing (i) certifying this Lease is unmodified and in full force and effect, or, if there have been modifications, this Lease is in full force and effect as modified, and stating any such modifications; (ii) certifying that Tenant has accepted possession of the Premises, and that any improvements required by the terms of this Lease to be made by the Landlord have been completed to the satisfaction of the Tenant or if not the case, any discrepancies therefrom; (iii) stating that no rent under this Lease has been paid more than thirty (30) days in advance of its due date or if not the case, any discrepancies therefrom; (iv) stating the address to which notices to Tenant should be sent; (v) certifying that Tenant, as of the date of any such certification, has no charge, lien or claim of set-off under this Lease, or otherwise, against rents or other charges due or to become due hereunder or if not the case, any discrepancies therefrom, and (vi) stating whether or not, to the best of Tenant's knowledge, Landlord is in default in the performance of any covenant, agreement or condition contained in this Lease, and, if so, specifying each such default of which Tenant may have knowledge and (vii) stating such other matters as Landlord may reasonably request. Any such statement delivered pursuant hereto may be relied upon by Landlord, any owner of the Building, any prospective purchaser of the Building, any mortgagee or prospective mortgagee of the building or of Landlord's interest, or any prospective assignee of any such mortgagee. Provided Tenant has received written notice of the mailing address of any mortgagee of Landlord, Tenant further agrees that, from the date of execution of this Lease, it will not seek to terminate this Lease by reason of any act or omission of the Landlord, until the Tenant shall have given written notice of such act or omission to Landlord's mortgagee and until a reasonable period of time shall have elapsed following the giving of such notice, during which period of time Landlord's mortgagee shall have the right, but shall not be obligated, to remedy such action or omission. 21 22 ARTICLE 28. FORCE MAJEURE Landlord shall not be required to perform any of its obligations under this Lease, nor be liable for loss or damage for failure to do so, nor shall Tenant thereby be released from any of its obligations under this Lease, where such failure arises from or through acts of God, strikes, lockouts, labor difficulties, explosions, sabotage, accidents, riots, civil commotions, acts of war, results of any warfare or warlike conditions in this or any foreign country, fire and casualty, legal requirements, energy shortage, or causes beyond the reasonable control of Landlord, unless such loss or damage results solely from willful misconduct or negligence of Landlord or its employees. Tenant shall not be required to perform any of its obligations under this Lease, nor be liable for loss or damage for failure to do so, nor shall Landlord be released from any of its obligations under this Lease, where such failure arises from or through such force majeure events that are beyond the reasonable control of Tenant, unless such loss or damage results solely from the willful misconduct or negligence of Tenant or its employees; provided, however, that in no event shall any such force majeure events excuse Tenant's obligations to pay any monetary amounts due under this Lease. ARTICLE 29. NO REPRESENTATIONS BY LANDLORD Neither Landlord nor any agent or employee of Landlord, has made any representations or promises, with respect to the Premises or the Building except as herein expressly set forth, and no rights, privileges, easements or licenses are acquired by Tenant except as herein set forth. ARTICLE 30. BROKER Tenant and Landlord warrant to each other that there are no other brokerage commissions or fees payable in connection with this Lease except to the Brokers named in Section 1.13 of this Lease, whose commission shall be paid by Landlord. Tenant and Landlord agree to indemnify, defend and hold each other harmless from any cost, liability and expense (including attorney's fees) which the indemnified party may incur as the result of any breach of the warranty contained in this Article 30. ARTICLE 31. ANNOUNCEMENTS [Intentionally Omitted] ARTICLE 32. COUNTERPARTS This Lease may be executed in two (2) or more counterparts, each of which shall be an original, but all of which shall constitute on and the same instrument. ARTICLE 33. GOVERNING LAW AND VENUE This Lease has been negotiated and entered into in the State of California, and shall be governed by, construed and enforced in accordance with the internal laws of the State of California applied to contracts made in California by California domiciliaries to be wholly performed in California. Venue for any action by any party pertaining to this Lease shall be in the appropriate court located in San Diego County, California. ARTICLE 34. CAPTIONS AND INTERPRETATIONS Articles, Sections , paragraph titles or other captions contained in this Lease are inserted as a matter of convenience and for reference and in no way define, limit, extend or describe the scope of this Lease or any provision hereof. No provision in this Lease is to be interpreted for or against either party because that party or its legal representative drafted such provision. 22 23 ARTICLE 35. SEVERABILITY If any term, covenant, condition or provision of this Lease is held by a court of competent jurisdiction to be invalid, void or unenforceable, the remainder of the provisions shall remain in full force and effect and shall in no way be affected, impaired or invalidated. ARTICLE 36. LEASE NOT EFFECTIVE UNTIL EXECUTED Submission by Landlord of this Lease for examination or signature by Tenant shall not constitute adoption and this Lease shall not become effective until executed by both Tenant and Landlord and delivery made of the fully executed instrument to such parties. The Lease shall not be deemed to be executed by Landlord until signed by an authorized General Partner of Landlord. ARTICLE 37. HAZARDOUS SUBSTANCES 37.1 Hazardous Substance Restriction. Tenant shall not cause or permit any Hazardous Substance to be used, stored, generated, or disposed of on or in the Premises by Tenant, Tenant's agents, employees, contractors, licensees, or invitees, except for Hazardous Substances used by Tenant in quantities typical for similar uses and in a manner in strict compliance with all federal, state and local laws, ordinances, rules, regulations, statutes, codes and orders ("Environmental Laws"). Tenant, at its sole cost and expense, shall comply with all Environmental Laws relating to the receiving, handling, use, storage, accumulation, transportation, generation, spillage, migration, discharge, release and disposal by or on behalf of Tenant of any Hazardous Substance in, on, under or about the Premises. If Hazardous Substances are used, stored, generated, or disposed of on or in the Premises in violation of the foregoing sentence, or if the Premises become contaminated in any manner due to an act or omission of Tenant, Tenant's agents, employees, contractors, licensees or invitees, Tenant shall indemnify, defend and hold harmless Landlord from any and all claims, damages, fines, judgments, penalties, costs, liabilities, or losses (including, without limitation, a decrease in value of the Premises, damages caused by loss or restriction of rentable or usable space), or any damages caused by adverse impact on marketing of the space, and any and all sums paid for settlement of claims, litigation expenses, reasonable attorney's fees, reasonable consultation, and reasonable expert fees of whatever kind or nature, known or unknown, contingent or otherwise arising therefrom. This indemnification includes, without limitation, any and all costs incurred because of any investigation of the site or any cleanup, removal, or restoration mandated by a federal, state, or local agency or political subdivision. Without limitation of the foregoing, if Tenant caused or permits the presence of any Hazardous Substances on the Premises and that results in contamination, Tenant shall promptly, at its sole expense, take any and all actions necessary to remediate any such Hazardous Substance and return the Premises to a condition that fully complies with all Environmental Laws. Tenant shall first obtain Landlord's approval for any such remedial action. The provisions of the paragraph 37.1 shall be in addition to any other obligations and liabilities Tenant may have to Landlord under this Lease or at law or equity and shall survive the transactions contemplated herein and shall survive the termination of this Lease. 37.2 Hazardous Substance Defined. As used in Section 37.1, "Hazardous Substance" means any substance that is toxic, ignitable, reactive, or corrosive and that is regulated by any local government, the State of California, or the United States Government. "Hazardous Substance" includes any and all material or substances that are defined as "hazardous waste", "extremely hazardous waste", or a "hazardous substance" or similar term pursuant to state, federal, or local governmental law now or hereafter enacted. "Hazardous Substance" includes, but is not restricted to, asbestos, polychlorobiphenyls ("PCB's), and petroleum products. 37.3 Landlord Indemnity. Landlord represents that, to Landlord's actual knowledge, without duty of inquiry or investigation, except as set forth in the Phase I environmental assessment of the Premises dated April 17, 1996, prepared by Douglas K. Eilar and previously provided to Tenant (the "Phase I"), as of the Commencement Date it is unaware of any Hazardous Substances present in, on, or under the Project in violation of Environmental Laws except as disclosed by the Phase I. Landlord agrees to indemnify, defend and hold Tenant harmless from and against any 23 24 and all claims, damages, fines, judgments, penalties, costs, liabilities or losses and expenses (including reasonable attorneys' fees and consultant and expert fees) arising from or relating to Hazardous Substances present within, on or under the Premises in violation of applicable laws prior to the Commencement Date, excluding, however, any Hazardous Substances brought onto the Premises by Tenant or any of its agents, employees or contractors. ARTICLE 38. RULES AND REGULATIONS Tenant agrees to abide by all rules and regulations of the building imposed by Landlord as set forth in Exhibit "B" attached to the Lease, as the same may be reasonably changed from time to time upon reasonable notice to Tenant provided they do not conflict with this Lease. Any violation of such Rules and Regulations which continues after written notice by Landlord shall constitute a default by Tenant, subject to the cure period set forth in Section 14.1(ii). Landlord shall enforce the rules and regulations in a non-discriminatory manner. Landlord shall not be liable for the failure of any Tenant, or its servants, employees, agents, contractors, licensees or invitees to conform to and comply with such rules and regulations. ARTICLE 39. ENTIRE AGREEMENT This Lease constitutes the entire agreement between the parties hereto pertaining to the subject matter hereof, and no oral statements or representations or prior written matter not contained or referred to herein shall have any force or effect. This Lease fully supersedes any and all prior understandings, representations, warranties and agreements between the parties hereto, or any of them, pertaining to the subject matter hereof, and may be modified only by written agreement, signed by all of the parties hereto. ARTICLE 40. SUBORDINATION, NON-DISTURBANCE AND ATTORNMENT AGREEMENT Tenant shall execute a Subordination, Non-Disturbance and Attornment Agreement substantially in the form attached hereto as Exhibit C upon Landlord's request. ARTICLE 41. RIGHT OF FIRST NEGOTIATION Provided Tenant is in occupancy and is leasing the entire Premises and provided Tenant is not in default of the terms and conditions of this Lease, Tenant shall have a first right of negotiation on the terms and conditions described below on all available space within the Project, subject to any existing renewal, expansion or similar rights of existing tenants. In the event Landlord receives an offer to lease any said available space that Landlord intends to accept, Landlord shall notify Tenant of such offer. If Tenant delivers written notice of Tenant's exercise of the right of first negotiation within two (2) business days after delivery of Landlord's notice, Landlord and Tenant shall meet and attempt negotiate in good faith terms which are acceptable to the parties, each in their sole and absolute discretion. If, within fifteen (15) days after Landlord's notice of an offer to Tenant, the parties have not entered into a lease agreement for any expansion, or Tenant does not elect to exercise its first right of negotiation within two (2) business days after delivery of Landlord's notice, then Landlord shall have the absolute right at any time within six (6) months thereafter to lease such space free of any rights of Tenant, provided that Tenant's right of first negotiation shall apply to such space if it again becomes available at the end of such lease. ARTICLE 42. OPTION TO RENEW 42.1 Grant of Option. Landlord hereby grants to Tenant one (1) option (the "Option") to renew the Term for a period of two (2) years (the "Extension"). During any Extension, the terms and conditions set forth in this Lease shall apply, except that Basic Rent for the Extension shall be adjusted to an amount equal to the prevailing market rate on the commencement date of such Extension. The Option shall be exercised only by written notice delivered to Landlord at least six (6) months, but not more than twelve (12) months, before the expiration of the initial Term of this Lease. If Tenant fails to timely deliver written notice of exercise of any Option to Landlord, the Option shall lapse, and Tenant shall have no further right to extend the Term of this Lease. If 24 25 Tenant so exercises the Option, then, effective on the commencement date of the applicable Extension, all references herein to the Term of this Lease shall include such Extension, except for references to the "initial Term." 42.2 Prevailing Market Rate. The term "prevailing market rate" shall mean the prevailing market rate on the commencement date of the applicable Extension (i) for leases for a comparable term to the Extension of comparable space within the Project or (ii) if no such comparable leases have been entered into during the prior twelve (12) months, for leases for a term equal to the term of the Extension of comparable space within similar buildings within the City of San Diego Scientific Research Zoning Ordinance, entered into during the preceding twelve (12) months, in either case giving appropriate consideration to rental rates per rentable square foot, rental escalations, rental abatements, tenant improvement allowances and other terms that would directly affect the economic terms of a Lease. Landlord and Tenant shall commence negotiation of the prevailing market rate within fifteen (15) days after Tenant delivers a written notice to Landlord of its exercise of an Option. If Landlord and Tenant do not agree, after good faith negotiations, within twenty (20) days, then each party shall submit to the other a proposal containing the prevailing market rate the submitting party believes to be correct ("Extension Proposal"). If either party fails to timely submit an Extension Proposal, the other party's submitted proposal shall determine the Basic Rent for the Extension. 42.3 Determination. If both parties submit Extension Proposals, then Landlord and Tenant shall meet within seven (7) days after delivery of the last Extension Proposal and make a good faith attempt to mutually appoint a certified MAI real estate appraiser who shall have been active full-time over the previous ten (10) years in the appraisal of comparable properties located in the San Diego area. If Landlord and Tenant are unable to agree upon a single appraiser, then each shall, within ten (10) days after the meeting, select an appraiser that meets the foregoing qualifications. The two (2) appraisers so appointed shall, within five (5) days after their appointment, appoint a third appraiser meeting the foregoing qualifications. The determination of the appraiser(s) shall be limited solely to the issue of whether Landlord's or Tenant's Extension Proposal most closely approximates the prevailing market rate. The decision of the single appropriate or of the appraiser(s) shall be made within thirty (30) days after the appointment of a single appraiser or the third appraiser, as applicable. The appraiser(s) shall have no authority to create an independent structure of prevailing market rate or prescribe or change any or several of the components or the structure of the prevailing market rate; the sole decision to be made shall be which of the parties' Extension Proposals shall determine the prevailing market rate for the Extension. The decision of the single appraiser or majority of the three (3) appraisers shall be binding upon the parties. If either party fails to appoint an appraiser within the time period specified above, the appraiser appointed by one of them shall reach a decision which shall be binding upon Landlord and Tenant. The cost of the appraisals shall be paid equally by Landlord and Tenant. If the prevailing market rate is not determined by the first day of the Extension, then Tenant shall pay Landlord Basic Rent in an amount equal to the Basic Rent in effect immediately prior to the Extension until such determination is made. After the determination of the prevailing market rate, the parties shall make any necessary adjustments to such payments made by Tenant. 42.4 Conditions to Exercise. Tenant's exercise of the Renewal Option(s) shall be subject to the express conditions that (i) at the time of exercise, and through the commencement of the Extension, Tenant shall not be in default hereunder beyond any applicable notice and cure period and (ii) Tenant has not been ten (10) or more days late in the payment of rent more than a total of three (3) times during the term of this Lease. The Option is personal to Tenant and cannot be transferred without Landlord's consent in accordance with this Lease except to an assignee pursuant to an assignment that does not require Landlord's consent under this Lease. In addition, Tenant may not exercise the Renewal Option(s) unless it then occupies at least fifty percent (50%) of the Premises. ARTICLE 43. QUIET ENJOYMENT Provided Tenant has performed all of the terms, covenants, agreements and conditions of this Lease, including the payment of Rent, to be performed by Tenant, Tenant shall peaceably and 25 26 quietly hold and enjoy the Premises for the term hereof, without hindrance from Landlord or any party claiming under or through Landlord, subject to the terms and conditions of this Lease. LANDLORD: PROFESSORS FUND I, L.P., AN ARIZONA LIMITED PARTNERSHIP, MANAGING AGENT FOR ALL SPECTRUM SERVICES, INC., A CALIFORNIA CORPORATION BY: /S/ ELIZABETH J. CLARQUIST ----------------------------------------- ELIZABETH J. CLARQUIST, GENERAL PARTNER TENANT: IDEC PHARMACEUTICALS CORPORATION, A CALIFORNIA CORPORATION BY: /S/ PHILLIP M. SCHNEIDER ----------------------------------------- TITLE: VICE PRESIDENT -------------------------------------- 26 27 EXHIBIT A PREMISES FLOOR PLAN 27 28 EXHIBIT A-1 Legal Description of Real Property Parcel A: Parcel 1 of Parcel Map No. 12041, in the City of San Diego, County of San Diego, State of California, filed in the Office of the County Recorder of San Diego County, April 2, 1982 as File No. 82-090385, of Official Records. Parcel B: An easement and right of way for ingress and egress, road and utility purposes, including but not limited to electric power, telephone, gas, water, sewer and cable television lines and appurtenances thereto, over, under, along and across those certain strips of land being 30.00 feet and 40.00 feet in width, the center line of said strips being described as follows: Commencing at the Northeasterly corner of Parcel 2 of Parcel Map No. 12041, in the county of San Diego, State of California, filed in the Office of the County Recorder of San Diego, April 2, 1982 as File No. 82-090385, of Official Records; thence South 64 (degrees) 19 (feet) 32 (inches) West 158.61 feet to the True Point of Beginning of said 30.00 foot strip; thence continuing South 64 (degrees) 19 (feet) 32 (inches) West 25.00 feet; thence South 14 (degrees) 42 (feet) 19 (inches) West 248.58 feet, to a point being the termination of said 30.00 foot strip, said point also being the beginning of said 40.00 foot strip; thence South 19 (degrees) 02 (feet) 41 (inches) East 393.00 feet to a point in the South line of said Parcel Map No. 12041, said point also being the point of termination. EXCEPTING THEREFROM that portion lying within Parcel A above. 28 29 EXHIBIT B RULES AND REGULATIONS Any violation of these rules and regulations, which continues after written notice by Landlord, shall constitute a default by Tenant, subject to the cure period set forth in Section 14.1(ii) of the Lease. Landlord may upon request by Tenant, waive the compliance by Tenant with any of the following rules and regulations, providing that (i) no waiver shall be effective unless signed by Landlord or Landlord's authorized agent, (ii) any such waiver shall not relieve Tenant from the obligation to comply with such rule or regulation in the future unless expressly consented to, in writing, by Landlord, and (iii) no waiver granted to any other tenant shall relieve Tenant from the obligation of complying with the following rules and regulations unless Tenant has received a similar waiver in writing from Landlord. 1. Landlord shall have the right to control and operate the public portions of the Building, and the facilities furnished for the common use of the tenants, in such manner as Landlord deems best for the benefit of the tenants generally. Tenant shall not permit the visit to the Premises of persons in such numbers or under such conditions as to interfere with the use and enjoyment by other tenants of the entrances, corridors, elevators and other public portions or facilities of the Building. 2. The directory board at the entrance to the Building is provided for the exclusive display of the name and location in the Building of each tenant, and Landlord reserves the right to exclude any other name therefrom, and to make a charge for each and every name in addition to the name of Tenant, placed on the directory board at the request of Tenant. 3. The water and janitor closets and other plumbing fixtures shall not be used for any purpose other than those for which they were constructed, and no sweepings, rubbish, rags, or other substances shall be thrown therein. All damages resulting from any misuse of the fixtures by Tenant or its servants, employees, agents, visitors or licensees shall be borne by Tenant. 4. Tenant shall see that the doors of the Premises are closed and securely locked before leaving the Premises, and must observe strict care and caution that all water faucets or water apparatus are shut off before Tenant or Tenant's employees leave and that all electricity shall likewise be carefully shut off, so as to prevent waste or damage, and for any default or carelessness Tenant shall make good all injuries sustained by other tenants or occupants of the Building or Landlord. 6. Tenant shall not install or use any machinery in the Premises which may cause any unreasonable noise, jar or tremor to the floors or walls, or which by its weight might injure the floors of the Building. Landlord may restrict the weight, size and position of all files, safes and heavy equipment used in the Building, and may require such items to be mounted on a wood or metal base acceptable to Landlord. All damage to the Building caused by installing or removing any safe, furniture, equipment or other property shall be repaired at the expense of Tenant. 11. Landlord reserves the right to exclude from the Building any person who, in the judgment of the Landlord, is intoxicated or under the influence of liquor or drugs or who is not known or does not property identify himself to the Building management or watchman on duty. landlord may, at its option, require all persons admitted to or leaving the Building during secured hours to register with Building security guards. Each tenant shall be responsible for all persons for whom he authorizes entry into the Building, and shall be liable to Landlord for all acts of such persons. 29 30 12. Canvassing, soliciting or peddling in the Building is prohibited and Tenant shall cooperate to prevent same. 13. Landlord shall have the right to prohibit any advertising by Tenant which in Landlord's opinion tends to impair the reputation of the Building or its desirability as a Building for offices, and upon written notice from Landlord, Tenant shall refrain from or discontinue such advertising. 14. Tenant shall not install blinds, shades, awnings or other form of inside or outside window coverings, or window ventilators or similar devices without the prior written consent of Landlord. 15. Tenant shall give Landlord prompt notice of any accidents to or defects in the water pipes, gas pipes, electric lights and fixtures, heating apparatus or any other service equipment in the Premises or Building. 19. The smoking of cigarettes or use of cigarettes or use of tobacco products in any form whatsoever is prohibited with the confines of the Premises. 20. Landlord reserves the right, from time to time, to make amendments to the foregoing rules and regulations by giving notice to Tenant provided such amendments do not conflict with the Lease. LANDLORD: PROFESSORS FUND I, L.P., AN ARIZONA LIMITED PARTNERSHIP, MANAGING AGENT FOR ALL SPECTRUM SERVICES, INC., A CALIFORNIA CORPORATION BY: /S/ ELIZABETH J. CLARQUIST ----------------------------------------- ELIZABETH J. CLARQUIST, GENERAL PARTNER TENANT: IDEC PHARMACEUTICALS, CORPORATION, A CALIFORNIA CORPORATION BY: /S/ PHILLIP M. SCHNEIDER ----------------------------------------- TITLE: VICE PRESIDENT --------------------------------------- 30
 

5 THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM THE CONDENSED CONSOLIDATED BALANCE SHEETS AND CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS CONTAINED IN THE COMPANY'S QUARTERLY REPORT ON FORM 10-Q FOR THE QUARTER ENDED SEPTEMBER 30, 1996 AND IS QUALIFIED IN ITS ENTIRETY BY REFERENCE TO SUCH FINANCIAL STATEMENTS AND THE NOTE THERETO 1,000 9-MOS DEC-31-1996 JAN-01-1996 JUN-30-1996 53,105 22,971 3,611 0 1,729 84,360 25,803 7,882 103,294 9,052 0 0 26,586 142,426 (82,558) 103,294 1,505 19,907 1,384 1,134 19,011 0 354 0 0 0 0 0 0 (6,147) (0.38) 0